Succinate-semialdehyde dehydrogenase (NAD(P)+) explained

succinate-semialdehyde dehydrogenase [NAD(P)+]
Ec Number:	1.2.1.16
Cas Number:	37250-88-7
Go Code:	0009013

In enzymology, a succinate-semialdehyde dehydrogenase [NAD(P)+] is an enzyme that catalyzes the chemical reaction

succinate semialdehyde + NAD(P)+ + H₂O

\rightleftharpoons succinate + NAD(P)H + 2 H⁺

The 4 substrates of this enzyme are succinate semialdehyde, NAD⁺, NADP⁺, and H₂O, whereas its 4 products are succinate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is succinate-semialdehyde:NAD(P)+ oxidoreductase. Other names in common use include succinate semialdehyde dehydrogenase (nicotinamide adenine, dinucleotide (phosphate)), and succinate-semialdehyde dehydrogenase [NAD(P)+]. This enzyme participates in 3 metabolic pathways: glutamate metabolism, tyrosine metabolism, and butanoate metabolism.

References

• Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
• JAKOBY WB, SCOTT EM . 1959 . Aldehyde oxidation. III. Succinic semialdehyde dehydrogenase . J. Biol. Chem. . 234 . 937 - 40 . 13654295 . 4 .
• Nirenberg MW . Jakoby WB . 1960 . Enzymatic utilization of gamma-hydroxybutyric acid . J. Biol. Chem. . 235 . 954 - 960 . 14427301.