Strictosidine beta-glucosidase explained

3α(S)-strictosidine β-glucosidase
Ec Number:	3.2.1.105
Cas Number:	73379-57-4

3α(S)-strictosidine β-glucosidase is an enzyme with systematic name strictosidine β-D-glucohydrolase.^{[1] [2] [3]} It catalyses the following chemical reaction:

strictosidine + H₂O

\rightleftharpoons D-glucose + strictosidine aglycone

It belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. It participates in indole and ipecac alkaloid biosynthesis.

Strictosidine is a precursor of indole alkaloids.

Notes and References

1. Hemscheidt T, Zenk MH . Glucosidases involved in indole alkaloid biosynthesis of Catharanthus cell cultures . FEBS Letters . 110 . 2 . 187–91 . February 1980 . 6768587 . 10.1016/0014-5793(80)80069-X . free .
2. Purification and characterisation of strictosidine β-D-glucosidase from Catharanthus roseus cell suspension cultures . Luijendijk TJ, Stevens LH, Verpoorte R . Plant Physiol. Biochem. . 1998 . 36 . 6 . 419–425 . 10.1016/S0981-9428(98)80205-2.
3. Barleben L, Ma X, Koepke J, Peng G, Michel H, Stöckigt J . Expression, purification, crystallization and preliminary X-ray analysis of strictosidine glucosidase, an enzyme initiating biosynthetic pathways to a unique diversity of indole alkaloid skeletons . Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics . 1747 . 1 . 89–92 . February 2005 . 15680242 . 10.1016/j.bbapap.2004.09.026 .