Strictamine Explained

Strictamine is an alkaloid isolated from Alstonia scholaris.^[1]

Because of its unusual chemical structure, it has attracted research interest and several laboratory syntheses have been reported.^{[2] [3] [4] [5]}

Notes and References

1. 500142 . 1979 . Bhattacharya . S. K. . Neuropharmacological studies on strictamine isolated from Alstonia scholaris . Indian Journal of Experimental Biology . 17 . 6 . 598–600 . Bose . R. . Dutta . S. C. . Ray . A. B. . Guha . S. R. .
2. 10.1021/acs.orglett.6b03839 . 28253628 . A 7-Step Formal Asymmetric Total Synthesis of Strictamine via an Asymmetric Propargylation and Metal-Mediated Cyclization . Organic Letters . 19 . 5 . 1004–1007 . 2017 . Smith . Myles W. . Zhou . Zhiyao . Gao . Alison X. . Shimbayashi . Takuya . Snyder . Scott A. .
3. 10.1002/anie.201901074. 30775833. Asymmetric Total Syntheses of the Akuammiline Alkaloids (−)-Strictamine and (−)-Rhazinoline. Angewandte Chemie International Edition. 58. 18. 6059–6063. 2019. Li. Wenfei. Chen. Zhitao. Yu. Di. Peng. Xin. Wen. Guohua. Wang. Siqi. Xue. Fei. Liu. Xiao-Yu. Qin. Yong. 73472189.
4. 10.1021/jacs.5b12880. 26783944. 5154302. Enantioselective Total Syntheses of Akuammiline Alkaloids (+)-Strictamine, (−)-2(S)-Cathafoline, and (−)-Aspidophylline A. Journal of the American Chemical Society. 138. 4. 1162–1165. 2016. Moreno. Jesus. Picazo. Elias. Morrill. Lucas A.. Smith. Joel M.. Garg. Neil K..
5. 10.1039/C7CC08153G. 29167841. Formal total synthesis of the akuammiline alkaloid (+)-strictamine. Chemical Communications. 53. 94. 12665–12667. 2017. Xiao. Tao. Chen. Zhi-Tao. Deng. Lin-Feng. Zhang. Dan. Liu. Xiao-Yu. Song. Hao. Qin. Yong.