Streptothricin hydrolase explained

Streptothricin hydrolase
Ec Number:	3.5.2.19

Streptothricin hydrolase (sttH (gene)) is an enzyme with systematic name streptothricin-F hydrolase.^{[1] [2]} This enzyme catalyses the following chemical reaction

streptothricin-F + H₂O

\rightleftharpoons streptothricin-F acid

The enzyme also catalyses the hydrolysis of streptothricin-D to streptothricin-D acid.

Notes and References

1. Maruyama C, Hamano Y . The biological function of the bacterial isochorismatase-like hydrolase SttH . Bioscience, Biotechnology, and Biochemistry . 73 . 11 . 2494–500 . November 2009 . 19897889 . 10.1271/bbb.90499 . free .
2. Hamano Y, Matsuura N, Kitamura M, Takagi H . A novel enzyme conferring streptothricin resistance alters the toxicity of streptothricin D from broad-spectrum to bacteria-specific . The Journal of Biological Chemistry . 281 . 25 . 16842–8 . June 2006 . 16641084 . 10.1074/jbc.m602294200 . free .