Streptopain Explained

Streptopain
Ec Number:3.4.22.10
Cas Number:9025-51-8

Streptopain, also known as streptococcal pyrogenic exotoxin B (SpeB) is a streptococcal cysteine protease.[1] [2] [3] [4] Other names include Streptococcus peptidase A, Streptococcus protease, and streptococcal cysteine proteinase. Streptopain catalyses the following chemical reaction

Preferential cleavage with hydrophobic residues at P2, P1 and P1'

It is isolated from the group A bacterium Streptococcus pyogenes and acts as a virulence factor.

See also

Notes and References

  1. Book: Streptococcal proteinase . Elliott SD, Liu TY . Methods Enzymol. . 1970 . 19 . 252–261 . 10.1016/0076-6879(70)19019-7. 978-0-12-181881-4 .
  2. Book: Streptococcal proteinase . The Enzymes . Liu TY, Elliott SD . 1971 . 609–647 . Boyer, P.D. . 3rd . Academic Press . New York .
  3. Tai JY, Kortt AA, Liu TY, Elliott SD . Primary structure of streptococcal proteinase. III. Isolation of cyanogen bromide peptides: complete covalent structure of the polypeptide chain . The Journal of Biological Chemistry . 251 . 7 . 1955–9 . April 1976 . 10.1016/S0021-9258(17)33640-2 . free . 1270417 .
  4. Lo SS, Fraser BA, Liu TY . The mixed disulfide in the zymogen of streptococcal proteinase. Characterization and implication for its biosynthesis . The Journal of Biological Chemistry . 259 . 17 . 11041–5 . September 1984 . 10.1016/S0021-9258(18)90619-8 . free . 6381494 .

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