Streptomycin-6-phosphatase explained

streptomycin-6-phosphatase
Ec Number:	3.1.3.39
Cas Number:	9055-33-8
Go Code:	0050301

The enzyme streptomycin-6-phosphatase (EC 3.1.3.39) catalyzes the reaction

streptomycin 6-phosphate + H₂O

\rightleftharpoons streptomycin + phosphate

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is streptomycin-6-phosphate phosphohydrolase. Other names in common use include streptomycin 6-phosphate phosphatase, streptomycin 6-phosphate phosphohydrolase, and streptomycin-6-P phosphohydrolase. This enzyme participates in streptomycin biosynthesis.

References

• Walker JB, Skorvaga M . 1973 . Streptomycin biosynthesis and metabolism. Phosphate transfer from dihydrostreptomycin 6-phosphate to inosamines, streptamine, and 2-deoxystreptamine . J. Biol. Chem. . 248 . 2441 - 6 . 4121457 . 7 .
• Walker MS, Walker JB . 1971 . Streptomycin biosynthesis. Separation and substrate specificities of phosphatases acting on guanidinodeoxy-scyllo-inositol phosphate and streptomycin-(streptidino)phosphate . J. Biol. Chem. . 246 . 7034 - 40 . 4331203 . 22 .