Streptogramin Explained

Streptogramins are a class of antibiotics.^[1]

Streptogramins are effective in the treatment of vancomycin-resistant Staphylococcus aureus (VRSA) and vancomycin-resistant Enterococcus (VRE), two of the most rapidly growing strains of multidrug-resistant bacteria. They fall into two groups: streptogramin A and streptogramin B.

Members include:

• Quinupristin/dalfopristin
• Pristinamycin
• Virginiamycin
• NXL 103, an experimental streptogramin in clinical trials for the treatment of respiratory tract infections.^[2]

Notes and References

1. http://www.bmb.leeds.ac.uk/mbiology/ug/ugteach/icu8/antibiotics/protein.html University of Leeds: Antimicrobial Chemotherapy
2. 19035777. 2009. Boucher. H. W.. Bad bugs, no drugs: No ESKAPE! An update from the Infectious Diseases Society of America. Clinical Infectious Diseases. 48. 1. 1–12. Talbot. G. H.. Bradley. J. S.. Edwards. J. E.. Gilbert. D. Rice. L. B.. Scheld. M. Spellberg. B. Bartlett. J. 10.1086/595011. free.