Steric exclusion explained

For chemical solutions, a Steric exclusion occurs when a solute molecule in water has a relatively larger hydrodynamic radius than water leading to a deficiency of the solute molecule in the vicinity of a second solute molecule (which must have some hydrophilic surfaces) of interest.^[1]

Notes and References

1. TSUTOMU ARAKAWA,JOHN F. CARPENTER, YOSHIKO A. KITA, AND JOHN H. CROWE, The Basis for Toxicity of Certain Cryoprotectants: A Hypothesis