Statine Explained

Statine is a gamma amino acid that occurs twice in the sequence of pepstatin, a protease inhibitor that is active against pepsin and other acid proteases.[1] It is thought to be responsible for the inhibitory activity of pepstatin because it mimics the tetrahedral transition state of peptide catalysis.[2]

Notes and References

  1. Umezawa . H. . Aoyagi . T. . Morishima . H. . Matsuzaki . M. . Hamada . M. . Takeuchi . T. . Pepstatin, a new pepsin inhibitor produced by Actinomycetes . The Journal of Antibiotics . 23 . 5 . 259–262 . 1970 . 4912600 . 10.7164/antibiotics.23.259. free .
  2. Marciniszyn Jr . J. . Hartsuck . J. A. . Tang . J. . Mode of inhibition of acid proteases by pepstatin . The Journal of Biological Chemistry . 251 . 22 . 7088–7094 . 1976 . 10.1016/S0021-9258(17)32945-9 . 993206. free .

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