STAB2 explained

Stabilin-2 is a protein that in humans is encoded by the STAB2 gene.^{[1] [2] [3]}

Function

This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on liver sinusoidal endothelial cells, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes.

Further reading

• Tamura Y, Adachi H, Osuga J, Ohashi K, Yahagi N, Sekiya M, Okazaki H, Tomita S, Iizuka Y, Shimano H, Nagai R, Kimura S, Tsujimoto M, Ishibashi S . FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products . The Journal of Biological Chemistry . 278 . 15 . 12613–7 . April 2003 . 12473645 . 10.1074/jbc.M210211200 . free .
• Zhou B, McGary CT, Weigel JA, Saxena A, Weigel PH . Purification and molecular identification of the human hyaluronan receptor for endocytosis . Glycobiology . 13 . 5 . 339–49 . May 2003 . 12626425 . 10.1093/glycob/cwg029 . free .
• Smedsrød B, Johansson S, Goerdt S . Shooting HARE . Glycobiology . 13 . 5 . 11G–12G; author reply 12G . May 2003 . 12751488 . 10.1093/glycob/cwg072 . free .
• Dobreva G, Dambacher J, Grosschedl R . SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression . Genes & Development . 17 . 24 . 3048–61 . December 2003 . 14701874 . 305257 . 10.1101/gad.1153003 .
• Harris EN, Weigel JA, Weigel PH . Endocytic function, glycosaminoglycan specificity, and antibody sensitivity of the recombinant human 190-kDa hyaluronan receptor for endocytosis (HARE) . The Journal of Biological Chemistry . 279 . 35 . 36201–9 . August 2004 . 15208308 . 10.1074/jbc.M405322200 . free .
• Hansen B, Longati P, Elvevold K, Nedredal GI, Schledzewski K, Olsen R, Falkowski M, Kzhyshkowska J, Carlsson F, Johansson S, Smedsrød B, Goerdt S, Johansson S, McCourt P . Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding . Experimental Cell Research . 303 . 1 . 160–73 . February 2005 . 15572036 . 10.1016/j.yexcr.2004.09.017 .
• Harris EN, Kyosseva SV, Weigel JA, Weigel PH . Expression, processing, and glycosaminoglycan binding activity of the recombinant human 315-kDa hyaluronic acid receptor for endocytosis (HARE) . The Journal of Biological Chemistry . 282 . 5 . 2785–97 . February 2007 . 17145755 . 10.1074/jbc.M607787200 . free .

Notes and References

1. Politz O, Gratchev A, McCourt PA, Schledzewski K, Guillot P, Johansson S, Svineng G, Franke P, Kannicht C, Kzhyshkowska J, Longati P, Velten FW, Johansson S, Goerdt S . Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues . The Biochemical Journal . 362 . Pt 1 . 155–64 . February 2002 . 11829752 . 1222372 . 10.1042/0264-6021:3620155 .
2. Adachi H, Tsujimoto M . FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities . The Journal of Biological Chemistry . 277 . 37 . 34264–70 . September 2002 . 12077138 . 10.1074/jbc.M204277200 . free .
3. Web site: Entrez Gene: STAB2 stabilin 2.