Slow-reacting substance of anaphylaxis explained

The slow-reacting substance of anaphylaxis or SRS-A is a mixture of the leukotrienes LTC4, LTD4 and LTE4. Mast cells secrete it during the anaphylactic reaction, inducing inflammation.[1] It can be found in basophils.

It induces prolonged, slow contraction of smooth muscle and has a major bronchoconstrictor role in asthma.[2] Compared to histamine, it is approximately 1000 times more potent and has a slower onset but longer duration of action.

References

  1. Web site: Dorland's Medical Dictionary. December 15, 2006. dead. https://web.archive.org/web/20070109225536/http://www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszSzcommonzSzdorlandszSzdorlandzSzdmd_s_27zPzhtm. January 9, 2007.
  2. Structure of slow-reacting substance of anaphylaxis from guinea-pig lung . Howard R. Morris . Graham W. Taylor . Priscilla J. Piper . John R. Tippins . Nature . 1980 . 285 . 5760 . 104–106 . 10.1038/285104a0 . 7374755 . 1980Natur.285..104M . December 15, 2006.

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