Squamous cell papilloma explained

Squamous cell papilloma
Synonyms:	Squamous papilloma

A squamous cell papilloma is a generally benign papilloma that arises from the stratified squamous epithelium of the skin, lip, oral cavity, tongue, pharynx, larynx, esophagus, cervix, vagina or anal canal.^{[1] [2] [3]} Squamous cell papillomas are typically associated with human papillomavirus (HPV) while sometimes the cause is unknown.^{[1] [2] [4] [5] [6] [7]}

Types

Oral squamous cell papilloma

Squamous cell papilloma of the mouth or throat is generally diagnosed in people between the ages of 30 and 50,^[1] and is normally found on the inside of the cheek, on the tongue, or inside of lips. Oral papillomas are usually painless, and not treated unless they interfere with eating or are causing pain.^[1] They do not generally mutate to cancerous growths, nor do they normally grow or spread. Oral papillomas are most usually a result of the infection with types HPV-6 and HPV-11.^[1]

Conjunctival squamous cell papilloma

Normally found in children or young adults, a common cause of conjunctival squamous cell papilloma is during childbirth, when the mother passes the virus to her child.^[1]

Diagnosis

It appears as an exophytic mass made of cauliflower appearance. The lesion may be white, red, or normal in color. It appears as sessile or pedunculated mass. Histopathology typically shows papillomatous protrusions and/or dysplasia.^[8]

Treatment

While most cases require no treatment, therapy options include cryotherapy, application of a topical salicylic acid compound, surgical excision and laser ablation.^{[1] [2]}

Notes and References

1. Web site: Squamous cell papilloma. December 19, 2007. New Zealand Dermatological Society. 2007. New Zealand Dermatological Society.
2. Web site: Squamous Cell Papilloma. December 19, 2007. Nikon Microscopy. 2007. Nikon Microscopy. dead. https://web.archive.org/web/20080113142819/http://www.microscopyu.com/galleries/pathology/squamouscellpapilloma.html. January 13, 2008.
3. Web site: Squamous cell papilloma. December 19, 2007. National Library for Health. 2007. National Library for Health. April 29, 2009. https://web.archive.org/web/20090429210028/http://www.library.nhs.uk/skin/ViewResource.aspx?resID=197171. dead.
4. Web site: Squamous cell papilloma . Ivan J. . Stojanov . PathologyOutlines.com. 2013. PathologyOutlines.com . 13 November 2021.
5. 117. 6. 722–732. 2014. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. Association of human papilloma virus with atypical and malignant oral papillary lesions. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 10.1016/j.oooo.2014.02.003. 24703405. free.
6. Squamous papilloma of the urinary tract. Cancer. 88. 7. 1679–1686. 2000. American Cancer Society. 10.1002/(SICI)1097-0142(20000401)88:7<1679::AID-CNCR23>3.0.CO;2-K. 10738227 . free.
7. Squamous cell papillomas of the esophagus. Human Pathology. 25. 5. 536–540. 1994. Elsevier Inc.. 10.1016/0046-8177(94)90128-7. 8200650.
8. Web site: Oral cavity - Other benign tumors / conditions - Squamous papilloma. Nat Pernick. pathology Outlines. Topic Completed: 1 November 2013. Revised: 1 February 2019