Some Spirurida, like the genus Gongylonema, can cause disease in humans. One such disease is a skin infection with Spirurida larvae, called "creeping disease". Some species are known as eyeworms and infect the orbital cavity of animal hosts.
The Camallanida are sometimes included herein as a suborder, and the Drilonematida are sometimes placed here as a superfamily. There are doubts about the internal systematics of the Spirurida, and some groups placed herein might belong to other spirurian or even secernentean lineages.[1]
The following superfamilies are at least provisionally placed in the Spirurida: