Spiroxasone Explained

Spiroxasone is a synthetic, steroidal antimineralocorticoid of the spirolactone group which was developed as a diuretic and antihypertensive agent but was never marketed.^{[1] [2]} It was synthesized and assayed in 1963. The drug is 7α-acetylthiospirolactone with the ketone group removed from the C17α spirolactone ring. Similarly to other spirolactones like spironolactone, spiroxasone also possesses antiandrogen activity.^{[3] [4]}

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 1114–.
2. Book: Morton IK, Hall JM . Concise Dictionary of Pharmacological Agents: Properties and Synonyms. 6 December 2012. Springer Science & Business Media. 978-94-011-4439-1. 261–.
3. Book: Progress in Medicinal Chemistry. 1 January 1979. Elsevier. 978-0-08-086264-4. 69–. Spiroxasone [...] is also an anti-androgen [379]..
4. Rasmusson GH, Chen A, Reynolds GF, Patanelli DJ, Patchett AA, Arth GE . Antiandrogens. 2',3' -Tetrahydrofuran-2'spiro-17-(1,2 -methylene-4-androsten-3-ones) . Journal of Medicinal Chemistry . 15 . 11 . 1165–1168 . November 1972 . 4654667 . 10.1021/jm00281a018 .