Spermosin Explained

Spermosin
Ec Number:	3.4.21.99
Cas Number:	89925-67-7

Spermosin is an enzyme.^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

Hydrolyses arginyl bonds, preferably with Pro in the P2 position

This enzyme is isolated from the ascidian (Prochordate) Halocynthia roretzi.

Notes and References

1. Sawada H, Yokosawa H, Ishii S . Purification and characterization of two types of trypsin-like enzymes from sperm of the ascidian (Prochordata) Halocynthia roretzi. Evidence for the presence of spermosin, a novel acrosin-like enzyme . The Journal of Biological Chemistry . 259 . 5 . 2900–4 . March 1984 . 6365918 .
2. Sawada H, Yokosawa H, Someno T, Saino T, Ishii S . Evidence for the participation of two sperm proteases, spermosin and acrosin, in fertilization of the ascidian, Halocynthia roretzi: inhibitory effects of leupeptin analogs on enzyme activities and fertilization . Developmental Biology . 105 . 1 . 246–9 . September 1984 . 6381175 . 10.1016/0012-1606(84)90281-1 .
3. Sawada H, Iwasaki K, Kihara-Negishi F, Ariga H, Yokosawa H . Localization, expression, and the role in fertilization of spermosin, an ascidian sperm trypsin-like protease . Biochemical and Biophysical Research Communications . 222 . 2 . 499–504 . May 1996 . 8670234 . 10.1006/bbrc.1996.0773 .
4. Sawada H, Someno T . Substrate specificity of ascidian sperm trypsin-like proteases, spermosin and acrosin . Molecular Reproduction and Development . 45 . 2 . 240–3 . October 1996 . 8914083 . 10.1002/(SICI)1098-2795(199610)45:2<240::AID-MRD18>3.0.CO;2-4 .