Spermine synthase explained
| Spermine synthase |
| Ec Number: | 2.5.1.22 |
| Cas Number: | 74812-43-4 |
Spermine synthase (spermidine aminopropyltransferase, spermine synthetase) is an enzyme that converts spermidine into spermine.[1] [2] This enzyme catalyses the following chemical reaction
S-methyl-5'-thioadenosine +
spermineSpermine synthase is an enzyme involved in
polyamine biosynthesis. It is present in all
eukaryotes and plays a role in a variety of biological functions in plants
[3] Its structure consists of two identical
monomers of 41 kDa with three domains each, creating a
homodimer formed via
dimerization. The interactions between one of the three domains, the N-terminals of the monomers, is responsible for dimerization as that is where the active site is located; the central terminal consisting of four
β- strands structurally forming a lid for the third domain, the C-terminal domain.
[4] Notes and References
- Hibasami H, Borchardt RT, Chen SY, Coward JK, Pegg AE . Studies of inhibition of rat spermidine synthase and spermine synthase . The Biochemical Journal . 187 . 2 . 419–28 . May 1980 . 10.1042/bj1870419 . 7396856 . 1161808 .
- Pajula RL, Raina A, Eloranta T . Polyamine synthesis in mammalian tissues. Isolation and characterization of spermine synthase from bovine brain . European Journal of Biochemistry . 101 . 2 . 619–26 . November 1979 . 520313 . 10.1111/j.1432-1033.1979.tb19756.x . free .
- Imamura T, Fujita K, Tasaki K, Higuchi A, Takahashi H . Characterization of spermidine synthase and spermine synthase--The polyamine-synthetic enzymes that induce early flowering in Gentiana triflora . Biochemical and Biophysical Research Communications . 463 . 4 . 781–6 . August 2015 . 26056006 . 10.1016/j.bbrc.2015.06.013 .
- Pegg AE, Michael AJ . Spermine synthase . Cellular and Molecular Life Sciences . 67 . 1 . 113–21 . January 2010 . 19859664 . 2822986 . 10.1007/s00018-009-0165-5 .
