Spermine oxidase explained

Spermine oxidase
Ec Number:	1.5.3.16

Spermine oxidase (PAOh1/SMO, AtPAO1, AtPAO4, SMO) is an enzyme with systematic name spermidine:oxygen oxidoreductase (spermidine-forming).^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

spermine + O₂ + H₂O

\rightleftharpoons spermidine + 3-aminopropanal + H₂O₂

The enzyme from Arabidopsis thaliana oxidizes norspermine to norspermidine.

Notes and References

1. Murray-Stewart T, Wang Y, Goodwin A, Hacker A, Meeker A, Casero RA . Nuclear localization of human spermine oxidase isoforms - possible implications in drug response and disease etiology . The FEBS Journal . 275 . 11 . 2795–806 . Jun 2008 . 18422650 . 10.1111/j.1742-4658.2008.06419.x . 3631774 .
2. Cervelli M, Polticelli F, Federico R, Mariottini P . Heterologous expression and characterization of mouse spermine oxidase . The Journal of Biological Chemistry . 278 . 7 . 5271–6 . Feb 2003 . 12458219 . 10.1074/jbc.M207888200 . free .
3. Tavladoraki P, Rossi MN, Saccuti G, Perez-Amador MA, Polticelli F, Angelini R, Federico R . Heterologous expression and biochemical characterization of a polyamine oxidase from Arabidopsis involved in polyamine back conversion . Plant Physiology . 141 . 4 . 1519–32 . Aug 2006 . 16778015 . 1533960 . 10.1104/pp.106.080911 .
4. Wang Y, Murray-Stewart T, Devereux W, Hacker A, Frydman B, Woster PM, Casero RA . Properties of purified recombinant human polyamine oxidase, PAOh1/SMO . Biochemical and Biophysical Research Communications . 304 . 4 . 605–11 . May 2003 . 12727196 . 10.1016/S0006-291X(03)00636-3 .