Spermidine dehydrogenase explained

spermidine dehydrogenase
Ec Number:	1.5.99.6
Cas Number:	9076-64-6
Go Code:	0050289

In enzymology, a spermidine dehydrogenase is an enzyme that catalyzes the chemical reaction

spermidine + acceptor + H₂O

\rightleftharpoons propane-1,3-diamine + 4-aminobutanal + reduced acceptor

The 3 substrates of this enzyme are spermidine, acceptor, and H₂O, whereas its 3 products are propane-1,3-diamine, 4-aminobutanal, and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donor with other acceptors. The systematic name of this enzyme class is spermidine:acceptor oxidoreductase. This enzyme is also called spermidine:(acceptor) oxidoreductase. This enzyme participates in urea cycle and metabolism of amino groups and beta-alanine metabolism. It has 2 cofactors: FAD, and Heme.

References

• Tabor CW, Kellogg PD . 1970 . Identification of flavin adenine dinucleotide and heme in a homogeneous spermidine dehydrogenase from Serratia marcescens . J. Biol. Chem. . 245 . 5424 - 33 . 4918845 . 20 .
• Tabor H . Tabor CW . 1972 . Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine, and related amines. IIE2a Speridine dehydrogenase . Adv. Enzymol. Relat. Areas Mol. Biol. . 36 . 225 - 226 .