Sorbitol-6-phosphate 2-dehydrogenase explained

sorbitol-6-phosphate 2-dehydrogenase
Ec Number:	1.1.1.140
Cas Number:	37250-69-4
Go Code:	0009010

In enzymology, a sorbitol-6-phosphate dehydrogenase is an enzyme that catalyzes the chemical reaction

D-sorbitol 6-phosphate + NAD⁺

\rightleftharpoons D-fructose 6-phosphate + NADH + H⁺

Thus, the two substrates of this enzyme are D-sorbitol 6-phosphate and NAD⁺, whereas its 3 products are D-fructose 6-phosphate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-sorbitol-6-phosphate:NAD⁺ 2-oxidoreductase. Other names in common use include ketosephosphate reductase, ketosephosphate reductase, D-sorbitol 6-phosphate dehydrogenase, D-sorbitol-6-phosphate dehydrogenase, sorbitol-6-P-dehydrogenase, and D-glucitol-6-phosphate dehydrogenase. This enzyme participates in fructose and mannose metabolism.

References

• Du Toit PJ, Kotze JP . 1970 . The isolation and characterization of sorbitol-6-phosphate dehydrogenase from Clostridium pasteurianum . Biochim. Biophys. Acta . 206 . 333–42 . 4318899 . 3 . 10.1016/0005-2744(70)90150-6.
• Liss M, Horwitz SB, Kaplan NO . 1962 . D-Mannitol 1-phosphate dehydrogenase and D-sorbitol 6-phosphate dehydrogenase in Aerobacter aerogenes . J. Biol. Chem. . 237 . 1342–50 . 14465816 .