Somatostatin receptor explained

somatostatin receptor 1
Hgncid:11330
Symbol:SSTR1
Entrezgene:6751
Omim:182451
Refseq:NM_001049
Uniprot:P30872
Chromosome:14
Arm:q
Band:13
somatostatin receptor 2
Hgncid:11331
Symbol:SSTR2
Entrezgene:6752
Omim:182452
Refseq:NM_001050
Uniprot:P30874
Chromosome:17
Arm:q
Band:24
somatostatin receptor 3
Hgncid:11332
Symbol:SSTR3
Entrezgene:6753
Omim:182453
Refseq:NM_001051
Uniprot:P32745
Chromosome:22
Arm:q
Band:13.1
somatostatin receptor 4
Hgncid:11333
Symbol:SSTR4
Entrezgene:6754
Omim:182454
Refseq:NM_001052
Uniprot:P31391
Chromosome:20
Arm:p
Band:11.2
somatostatin receptor 5
Hgncid:11334
Symbol:SSTR5
Entrezgene:6755
Omim:182455
Refseq:NM_001053
Uniprot:P35346
Chromosome:16
Arm:p
Band:13.3

Somatostatin receptors are receptors for the ligand somatostatin, a small neuropeptide associated with neural signaling, particularly in the post-synaptic response to NMDA receptor co-stimulation/activation. Somatostatin is encoded by a CRE and is very susceptible to gene promoter region activation by transcription factor CREB.[1]

There are five known somatostatin receptors:[2]

All are G protein-coupled seven transmembrane receptors.

References

  1. Book: Lou, Liqun . Principles of Neurobiology. vanc . Garland Science, Taylor and Francis Group. 2016. 978-0-8153-4494-0. New York, NY. 109–110.
  2. Hoyer D, Bell GI, Berelowitz M, Epelbaum J, Feniuk W, Humphrey PP, O'Carroll AM, Patel YC, Schonbrunn A, Taylor JE . Classification and nomenclature of somatostatin receptors . Trends Pharmacol. Sci. . 16 . 3 . 86–8 . 1995 . 7792934 . 10.1016/S0165-6147(00)88988-9 . free .