Somatostatin receptor explained
somatostatin receptor 1 |
Hgncid: | 11330 |
Symbol: | SSTR1 |
Entrezgene: | 6751 |
Omim: | 182451 |
Refseq: | NM_001049 |
Uniprot: | P30872 |
Chromosome: | 14 |
Arm: | q |
Band: | 13 |
somatostatin receptor 2 |
Hgncid: | 11331 |
Symbol: | SSTR2 |
Entrezgene: | 6752 |
Omim: | 182452 |
Refseq: | NM_001050 |
Uniprot: | P30874 |
Chromosome: | 17 |
Arm: | q |
Band: | 24 |
somatostatin receptor 3 |
Hgncid: | 11332 |
Symbol: | SSTR3 |
Entrezgene: | 6753 |
Omim: | 182453 |
Refseq: | NM_001051 |
Uniprot: | P32745 |
Chromosome: | 22 |
Arm: | q |
Band: | 13.1 |
somatostatin receptor 4 |
Hgncid: | 11333 |
Symbol: | SSTR4 |
Entrezgene: | 6754 |
Omim: | 182454 |
Refseq: | NM_001052 |
Uniprot: | P31391 |
Chromosome: | 20 |
Arm: | p |
Band: | 11.2 |
somatostatin receptor 5 |
Hgncid: | 11334 |
Symbol: | SSTR5 |
Entrezgene: | 6755 |
Omim: | 182455 |
Refseq: | NM_001053 |
Uniprot: | P35346 |
Chromosome: | 16 |
Arm: | p |
Band: | 13.3 |
Somatostatin receptors are receptors for the ligand somatostatin, a small neuropeptide associated with neural signaling, particularly in the post-synaptic response to NMDA receptor co-stimulation/activation. Somatostatin is encoded by a CRE and is very susceptible to gene promoter region activation by transcription factor CREB.[1]
There are five known somatostatin receptors:[2]
All are G protein-coupled seven transmembrane receptors.
References
- Book: Lou, Liqun . Principles of Neurobiology. vanc . Garland Science, Taylor and Francis Group. 2016. 978-0-8153-4494-0. New York, NY. 109–110.
- Hoyer D, Bell GI, Berelowitz M, Epelbaum J, Feniuk W, Humphrey PP, O'Carroll AM, Patel YC, Schonbrunn A, Taylor JE . Classification and nomenclature of somatostatin receptors . Trends Pharmacol. Sci. . 16 . 3 . 86–8 . 1995 . 7792934 . 10.1016/S0165-6147(00)88988-9 . free .