Sodium orthovanadate explained

Sodium orthovanadate is the inorganic compound with the chemical formula . It forms a dihydrate . Sodium orthovanadate is a salt of the oxyanion. It is a colorless, water-soluble solid.

Synthesis and structure

Sodium orthovanadate is produced by dissolving vanadium(V) oxide in a solution of sodium hydroxide:

The salt features tetrahedral anion centers linked to octahedral cation sites.[1]

Condensation equilibria

Like many oxometalates, orthovanadate is subject to a number of reactions, which have been analyzed by 51V NMR studies. At high pH, ions exist in equilibrium with .[2] At lower pH's, condensation ensues to give various polyoxovanadates. Ultimately, decavanadate is formed.[3]

Biochemistry

Vanadates exhibit a variety of biological activities, in part because they serve as structural mimics of phosphates.[4] [5] It acts as a competitive inhibitor of ATPases, alkaline and acid phosphatases, and protein-phosphotyrosine phosphatases, and its inhibitory effects can be reversed by dilution or the addition of ethylenediaminetetraacetic acid (EDTA).[6]

Orthovanadate is activated by boiling and adjusting pH to ~10; this depolymerizes decavanadate into the active inhibitor, monovanadate.[7]

See also

Notes and References

  1. Kato. K.. Takayama-Muromachi. E. . Die Struktur des Trinatriumvanadattrihydrats. The structure of trisodium vanadate trihydrate. Acta Crystallogr.. 1987 . C43 . 6. 1030–1032. 10.1107/S0108270187093120. 1987AcCrC..43.1030K.
  2. Book: 10.1016/S0066-4103(07)62002-X. Vanadium-51 NMR. Annual Reports on NMR Spectroscopy. 2007. Rehder. D.. Polenova. T.. Bühl. M.. 62. 49–114. 9780123739193.
  3. Walter G. Klemperer. W. G. . Klemperer . Omar M. Yaghi. O.. Yaghi . Tetrabutylammonium Trihydrogen Decavanadate(V) . Inorg. Synth.. 1983 . 27 . 83. 10.1002/9780470132586.ch15.
  4. Korbecki. Jan. Baranowska-Bosiacka. Irena. Gutowska. Izabela. Chlubek. Dariusz . Biochemical and medical importance of vanadium compounds . Acta Biochim. Pol. . 2012 . 59 . 2. 195–200. 10.18388/abp.2012_2138. 22693688. free.
  5. Encyclopedia: Crans. D. C.. Chatterjee. P. B.. Vanadium biochemistry . Reedijk. Jan. Poeppelmeier. Kenneth . Comprehensive Inorganic Chemistry II . 2013 . 3 . 323–342. 10.1016/B978-0-08-097774-4.00324-7. 978-0-08-097774-4. Comprehensive Inorganic Chemistry II: From Elements to Applications.
  6. Web site: Sodium Orthovanadate (Vanadate) NEB. Biolabs. New England. www.neb.com. en. 2018-09-07.
  7. Web site: Sodium orthovanadate. Sigma-Aldrich. September 7, 2018.

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