Sodium glycerophosphate explained

Tradename:Glycophos
Pregnancy Au Comment:Exempt[1]
Routes Of Administration:Intravenous infusion
Atc Prefix:B05
Atc Suffix:XA14
Legal Au:Unscheduled
Legal Au Comment:[2]
Cas Number:1334-74-3
Cas Number2:55073-41-1
Pubchem:22251426
Drugbank:DB09561
Chemspiderid:14071
Unii:YP1H63LJ2K
Unii2:RCS9EQ01V4
Kegg:D10489
Chembl:3040581
Iupac Name:disodium 3-(phosphonooxy)propane-1,2-diol
C:3
H:7
Na:2
O:6
P:1
Smiles:[Na+].[Na+].OCC(O)COP([O-])([O-])=O
Stdinchi:1S/C3H9O6P.2Na/c4-1-3(5)2-9-10(6,7)8;;/h3-5H,1-2H2,(H2,6,7,8);;/q;2*+1/p-2
Stdinchikey:GEKBIENFFVFKRG-UHFFFAOYSA-L
Stdinchikey2:OFNNKPAERNWEDD-UHFFFAOYSA-L
Melting Point:98
Melting High:100
Solubility:very soluble

Sodium glycerophosphate, sold under the brand name Glycophos, is a medication used to supplement phosphate. It is administered via intravenous infusion.

Sodium glycerophosphate is an organic phosphate salt.[3]

It was approved for medical use in Australia in November 2019.[4] [5]

It is an unapproved medication in the United States that was used as a substitute for inorganic phosphate during a drug shortage.[6]

Chemistry

The substance is a mixture of disodium glycerol 1- and 2-phosphates, which have different amounts of water of crystallization; the total amount is H2O per glycerol phosphate molecule. It is a white to off-white powder which may or may not be crystalline, has no discernible odor and tastes salty. It melts at NaNC and decomposes at 130C. Aqueous solutions have a pH of about 9.5.[7]

Notes and References

  1. Web site: Glycophos APMDS . Therapeutic Goods Administration (TGA) . 26 May 2022 . 10 March 2024.
  2. Web site: Australian Public Assessment Report for Sodium glycerophosphate (as hydrate) . Therapeutic Goods Administration (TGA) .
  3. Web site: ARTG Entry:312021 Glycophos Product Information . Therapeutic Goods Administration (TGA) . PDF . 23 August 2020.
  4. Web site: Glycophos Australian prescription medicine decision summary . Therapeutic Goods Administration (TGA) . 23 August 2020.
  5. Web site: Summary for ARTG Entry:312021 Glycophos sodium glycerophosphate (as hydrate) 4.32 g/20 mL concentrated solution for injection ampoule . Therapeutic Goods Administration (TGA) . 23 August 2020 . 18 April 2021 . https://web.archive.org/web/20210418073738/https://tga-search.clients.funnelback.com/s/search.html?collection=tga-artg&profile=record&meta_i=312021 . dead .
  6. Web site: Glycophos- sodium glycolate injection, solution . DailyMed . 16 January 2019 . 23 August 2020.
  7. Book: Hagers Handbuch der pharmazeutischen Praxis. 15 August 1977. 4th. VI.A. 91–92. Springer. de. 3-540-05123-6.