Snake venom factor V activator explained

Snake venom factor V activator
Ec Number:	3.4.21.95
Cas Number:	471269-12-2

Snake venom factor V activator is an enzyme.^{[1] [2]} This enzyme catalyses the following chemical reaction

Fully activates human clotting factor V by a single cleavage at the Trp-Tyr-Leu-Arg1545-Ser-Asn-Asn-Gly bond.

This enzyme is present in venom of Daboia russelii.

Notes and References

1. Book: Kisiel W, Canfield WM . Snake venom proteases that activate blood-coagulation factor V . Proteolytic Enzymes, Part C . Methods in Enzymology . 80 Pt C . 275–85 . 1981 . 7043192 . 10.1016/s0076-6879(81)80024-9 . 978-0-12-181980-4 .
2. Tokunaga F, Nagasawa K, Tamura S, Miyata T, Iwanaga S, Kisiel W . The factor V-activating enzyme (RVV-V) from Russell's viper venom. Identification of isoproteins RVV-V alpha, -V beta, and -V gamma and their complete amino acid sequences . The Journal of Biological Chemistry . 263 . 33 . 17471–81 . November 1988 . 10.1016/S0021-9258(19)77860-0 . free . 3053712 .