Stigmastanol Explained

Stigmastanol (sitostanol) is a phytosterol found in a variety of plant sources. Similar to sterol esters and stanol esters, stigmastanol inhibits the absorption of cholesterol from the diet.[1] [2] [3] Animal studies suggest that it also inhibits biosynthesis of cholesterol in the liver.

Stigmastanol is the product of the reduction of β-sitosterol[4] and the hydrogenation of stigmasterol.[5]

See also

Notes and References

  1. Batta, Ashok K. . Xu, Guorong . Honda, Akira . Miyazaki, Teruo . Salen, Gerald . Stigmasterol reduces plasma cholesterol levels and inhibits hepatic synthesis and intestinal absorption in the rat . Metabolism: Clinical and Experimental . 2006 . 55 . 3 . 292–299 . 10.1016/j.metabol.2005.08.024. 16483871 .
  2. Heinemann T, Pietruck B, Kullak-Ublick G, von Bergmann K . Comparison of sitosterol and sitostanol on inhibition of intestinal cholesterol absorption . Agents and Actions. Supplements . 1988 . 26 . 117–122 . 3265272.
  3. 10.1007/BF01409411 . Heinemann T, Kullak-Ublick GA, Pietruck B, von Bergmann K . Mechanisms of action of plant sterols on inhibition of cholesterol absorption. Comparison of sitosterol and sitostanol . European Journal of Clinical Pharmacology . 1991 . 40 . Suppl 1 . S59–63 . 2044646. 23279253 .
  4. Book: Thomasson Crompton. David William. Nickol. Brent B.. Biology of the Acanthocephala. 1985. Cambridge University Press. 9780521246743. 185.
  5. Book: Paxena. P. B.. Chemistry of Alkaloids. 2007. Discovery Publishing Hous. 9788183563161. 231.

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