STAT1 explained

Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the STAT protein family.[1]

Function

All STAT molecules are phosphorylated by receptor associated kinases, that causes activation, dimerization by forming homo- or heterodimers and finally translocate to nucleus to work as transcription factors. Specifically STAT1 can be activated by several ligands such as Interferon alpha (IFNα), Interferon gamma (IFNγ), Epidermal Growth Factor (EGF), Platelet Derived Growth Factor (PDGF), Interleukin 6 (IL-6), or IL-27.[2]

Type I interferons (IFN-α, IFN-ß) bind to receptors, cause signaling via kinases, phosphorylate and activate the Jak kinases TYK2 and JAK1 and also STAT1 and STAT2. STAT molecules form dimers and bind to ISGF3G/IRF-9, which is Interferon stimulated gene factor 3 complex with Interferon regulatory Factor 9.[3] This allows STAT1 to enter the nucleus.[4] STAT1 has a key role in many gene expressions that cause survival of the cell, viability or pathogen response. There are two possible transcripts (due to alternative splicing) that encode 2 isoforms of STAT1.[5] [6] STAT1α, the full-length version of the protein, is the main active isoform, responsible for most of the known functions of STAT1. STAT1ß, which lacks a portion of the C-terminus of the protein, is less-studied, but has variously been reported to negatively regulate activation of STAT1 or to mediate IFN-γ-dependent anti-tumor and anti-infection activities.[7] [8] [9]

STAT1 is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. In response to IFN-γ stimulation, STAT1 forms homodimers or heterodimers with STAT3 that bind to the GAS (Interferon-Gamma-Activated Sequence) promoter element; in response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the ISRE (Interferon-Stimulated Response Element) promoter element.[10] In either case, binding of the promoter element leads to an increased expression of ISG (Interferon-Stimulated Genes).

Expression of STAT1 can be induced with diallyl disulfide, a compound in garlic.[11]

Mutations of STAT1

Mutations in the STAT1 molecule can be gain of function (GOF) or loss of function (LOF). Both of them can cause different phenotypes and symptoms. Recurring common infections are frequent in both GOF and LOF mutations. In humans STAT1 has been particularly under strong purifying selection when populations shifted from hunting and gathering to farming, because this went along with a change in the pathogen spectrum.[12]

Loss of function

STAT1 loss of function, therefore STAT1 deficiency can have many variants. There are two main genetic impairments that can cause response to interferons type I and III. First there can be autosomal recessive partial or even complete deficiency of STAT1. That causes intracellular bacterial diseases or viral infections and impaired IFN a, b, g and IL27 responses are diagnosed. In partial form there can also be found high levels of IFNg in blood serum. When tested from whole blood, monocytes do not respond to BCG and IFNg doses with IL-12 production. In complete recessive form there is a very low response to anti-viral and antimycotical medication. Second, partial STAT1 deficiency can also be an autosomal dominant mutation; phenotypically causing impaired IFNg responses and causing patients to suffer with selective intracellular bacterial diseases (MSMD).[13]

In knock-out mice prepared in the 90s, a low amount of CD4+ and CD25+ regulatory T-cells and almost no IFNa, b and g response was discovered, which lead to parasital, viral and bacterial infections. The very first reported case of STAT1 deficiency in human was an autosomal dominant mutation and patients were showing propensity to mycobacterial infections.[5] Another case reported was about an autosomal recessive form. 2 related patients had a homozygous missense STAT1 mutation which caused impaired splicing, therefore a defect in mature protein. Patients had partially damaged response to both IFNa and IFNg. Scientists now claim that recessive STAT1 deficiency is a new form of primary immunodeficiency and whenever a patient suffers sudden, severe and unexpected bacterial and viral infections, should be considered as potentially STAT1 deficient.[14] [15]

Interferons induce the formation of two transcriptional activators: gamma-activating factor (GAF) and interferon-stimulated gamma factor 3 (ISGF3). A natural heterozygous germline STAT1 mutation associated with susceptibility to mycobacterial but not viral disease was found in two unrelated patients with unexplained mycobacterial disease.[16] This mutation caused a loss of GAF and ISGF3 activation but was dominant for one cellular phenotype and recessive for the other. It impaired the nuclear accumulation of GAF but not of ISGF3 in cells stimulated by interferons, implying that the antimycobacterial but not the antiviral effects of human interferons are mediated by GAF. More recently, two patients have been identified with homozygous STAT-1 mutations who developed both post–BCG vaccination disseminated disease and lethal viral infections. The mutations in these patients caused a complete lack of STAT-1 and resulted in a lack of formation of both GAF and ISGF3.[17]

Gain of function

Gain of function mutation was first discovered in patients with chronic mucocutaneous candidiasis (CMC). This disease is characteristic with its symptoms as persistent infections of the skin, mucosae - oral or genital and nails infections caused by Candida, mostly Candida albicans. CMC may very often result from primary immunodeficiency. Patients with CMC often suffer also with bacterial infections (mostly Staphylococcus aureus), also with infections of the respiratory system and skin. In these patients we can also find viral infections caused mostly by Herpesviridae, that also affect the skin. The mycobacterial infections are often caused by Mycobacterium tuberculosis or environmental bacteria. Very common are also autoimmune symptoms like type 1 diabetes, cytopenia, regression of the thymus or systemic lupus erythematosus. When T-cell deficient, these autoimmune díseases are very common. CMC was also reported as a common symptom in patients with hyper immunoglobulin E syndrome (hyper-IgE) and with autoimmune polyendocrine syndrome type I. There was reported an interleukin 17A role, because of low levels of IL-17A producing T-cells in CMC patients.

With various genomic and genetic methods was discovered, that a heterozygous gain of function mutation of STAT1 is a cause of more than a half CMC cases. This mutation is caused by defect in the coiled-coil domain, domain that binds DNA, N-terminal domain or SH2 domain. Because of this there is increased phosphorylation because of impossible dephosphorylation in nucleus. These processes are dependent on cytokines like interferon alpha or beta, interferon gamma or interleukin 27. As mentioned above, low levels of interleukin 17A were observed, therefore impaired the Th17 polarization of the immune response.

Patients with STAT1 gain of function mutation and CMC poorly or not at all respond to treatment with azole drugs such as Fluconazole, Itraconazole or Posaconazole. Besides common viral and bacterial infections, these patients develop autoimmunities or even carcinomas. It is very complicated to find a treatment because of various symptoms and resistances, inhibitors of JAK/STAT pathway such as Ruxolitinib are being tested and are a possible choice of treatment for these patients.[18] [19]

Interactions

STAT1 has been shown to interact with:

Further reading

Notes and References

  1. Subedi P, Huber K, Sterr C, Dietz A, Strasser L, Kaestle F, Hauck SM, Duchrow L, Aldrian C, Monroy Ordonez EB, Luka B, Thomsen AR, Henke M, Gomolka M, Rößler U, Azimzadeh O, Moertl S, Hornhardt S . 6 . Towards unravelling biological mechanisms behind radiation-induced oral mucositis via mass spectrometry-based proteomics . Frontiers in Oncology . 13 . 1180642 . 2023 . 37384298 . 10298177 . 10.3389/fonc.2023.1180642 . free .
  2. Baris S, Alroqi F, Kiykim A, Karakoc-Aydiner E, Ogulur I, Ozen A, Charbonnier LM, Bakır M, Boztug K, Chatila TA, Barlan IB . Severe Early-Onset Combined Immunodeficiency due to Heterozygous Gain-of-Function Mutations in STAT1 . Journal of Clinical Immunology . 36 . 7 . 641–8 . October 2016 . 27379765 . 10.1007/s10875-016-0312-3 . 5556363.
  3. Subedi P, Huber K, Sterr C, Dietz A, Strasser L, Kaestle F, Hauck SM, Duchrow L, Aldrian C, Monroy Ordonez EB, Luka B, Thomsen AR, Henke M, Gomolka M, Rößler U, Azimzadeh O, Moertl S, Hornhardt S . 6 . Towards unravelling biological mechanisms behind radiation-induced oral mucositis via mass spectrometry-based proteomics . Frontiers in Oncology . 13 . 1180642 . 2023 . 37384298 . 10298177 . 10.3389/fonc.2023.1180642 . free .
  4. Web site: IRF9 Gene - GeneCards IRF9 Protein IRF9 Antibody . GeneCards Human Gene Database . 2017-06-01.
  5. Web site: STAT1 - Signal transducer and activator of transcription 1-alpha/beta - Homo sapiens (Human) - STAT1 gene & protein. www.uniprot.org. 2017-06-01.
  6. Web site: STAT1 signal transducer and activator of transcription 1 [Homo sapiens (human)] - Gene - NCBI]. www.ncbi.nlm.nih.gov. 2017-06-01.
  7. Baran-Marszak F, Feuillard J, Najjar I, Le Clorennec C, Béchet JM, Dusanter-Fourt I, Bornkamm GW, Raphaël M, Fagard R . 6 . Differential roles of STAT1alpha and STAT1beta in fludarabine-induced cell cycle arrest and apoptosis in human B cells . Blood . 104 . 8 . 2475–2483 . October 2004 . 15217838 . 10.1182/blood-2003-10-3508 . free .
  8. Zhang Y, Chen Y, Yun H, Liu Z, Su M, Lai R . STAT1β enhances STAT1 function by protecting STAT1α from degradation in esophageal squamous cell carcinoma . Cell Death & Disease . 8 . 10 . e3077 . October 2017 . 28981100 . 5682650 . 10.1038/cddis.2017.481 .
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  15. Web site: Defects of STAT1 in Human. Loss of Function exposes to Mycobacteria. Gain of Function exposes to Candida. www.asid.ma-gb. 2017-06-01. 2017-08-29. https://web.archive.org/web/20170829122455/http://www.asid.ma/en/ressources/mini-reviews/171-defects-of-stat1-in-human-loss-of-function-exposes-to-mycobacteria-gain-of-function-exposes-to-candida.html. dead.
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  40. Wong AH, Durbin JE, Li S, Dever TE, Decker T, Koromilas AE . Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR . The Journal of Biological Chemistry . 276 . 17 . 13727–37 . April 2001 . 11278865 . 10.1074/jbc.M011240200 . free .
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  42. Dumler I, Kopmann A, Wagner K, Mayboroda OA, Jerke U, Dietz R, Haller H, Gulba DC . Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells . The Journal of Biological Chemistry . 274 . 34 . 24059–65 . August 1999 . 10446176 . 10.1074/jbc.274.34.24059 . free .
  43. Fagerlund R, Mélen K, Kinnunen L, Julkunen I . Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5 . The Journal of Biological Chemistry . 277 . 33 . 30072–8 . August 2002 . 12048190 . 10.1074/jbc.M202943200 . free .
  44. Xia L, Wang L, Chung AS, Ivanov SS, Ling MY, Dragoi AM, Platt A, Gilmer TM, Fu XY, Chin YE . Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation . The Journal of Biological Chemistry . 277 . 34 . 30716–23 . August 2002 . 12070153 . 10.1074/jbc.M202823200 . free .
  45. Gunaje JJ, Bhat GJ . Involvement of tyrosine phosphatase PTP1D in the inhibition of interleukin-6-induced Stat3 signaling by alpha-thrombin . Biochemical and Biophysical Research Communications . 288 . 1 . 252–7 . October 2001 . 11594781 . 10.1006/bbrc.2001.5759 .
  46. Spiekermann K, Biethahn S, Wilde S, Hiddemann W, Alves F . Constitutive activation of STAT transcription factors in acute myelogenous leukemia . European Journal of Haematology . 67 . 2 . 63–71 . August 2001 . 11722592 . 10.1034/j.1600-0609.2001.t01-1-00385.x . 38074766 .
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  48. Cirri P, Chiarugi P, Marra F, Raugei G, Camici G, Manao G, Ramponi G . c-Src activates both STAT1 and STAT3 in PDGF-stimulated NIH3T3 cells . Biochemical and Biophysical Research Communications . 239 . 2 . 493–7 . October 1997 . 9344858 . 10.1006/bbrc.1997.7493 .
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