Signal peptidase II explained

Signal peptidase II
Ec Number:	3.4.23.36
Cas Number:	171715-14-3

Signal peptidase II (premurein-leader peptidase, prolipoprotein signal peptidase, leader peptidase II, premurein leader proteinase) is an enzyme.^{[1] [2] [3]}

This enzyme catalyses a chemical reaction. It releases signal peptides from murein prolipoprotein and other bacterial membrane prolipoproteins. It also hydrolyses -Xaa-Yaa-Zaa-(S,diacylglyceryl)Cys-, in which Yaa (Ala or Ser) and Zaa (Gly or Ala) have small neutral sidechains, and Xaa is hydrophobic (preferably Leu).

This enzyme is present in bacterial inner membranes.

Notes and References

1. Dev IK, Ray PH . Signal peptidases and signal peptide hydrolases . Journal of Bioenergetics and Biomembranes . 22 . 3 . 271–90 . June 1990 . 2202720 . 10.1007/bf00763168 .
2. Zhao XJ, Wu HC . Nucleotide sequence of the Staphylococcus aureus signal peptidase II (lsp) gene . FEBS Letters . 299 . 1 . 80–4 . March 1992 . 1544479 . 10.1016/0014-5793(92)80105-p .
3. Book: Sankaran K, Wu HC . Bacterial prolipoprotein signal peptidase . Methods in Enzymology . 248 . 169–80 . 1995 . 7674920 . 10.1016/0076-6879(95)48014-5 .