Signal-regulatory protein explained

A Signal-regulatory protein (SIRP) is one of a family of transmembrane glycoproteins involved in immunological signalling, expressed mainly by myeloid cells.^{[1] [2]}

Members include :

• Signal-regulatory protein alpha, ligand=CD47^[1]
• SIRPB1
• SIRPB2^[3]
• SIRPD
• SIRPG, ligand=CD47^[1]

Notes and References

1. van Beek EM, Cochrane F, Barclay AN, van den Berg TK . Signal regulatory proteins in the immune system . Journal of Immunology . 175 . 12 . 7781–7 . December 2005 . 16339510 . 10.4049/jimmunol.175.12.7781 . free .
2. Barclay AN, Brown MH . The SIRP family of receptors and immune regulation . Nature Reviews. Immunology . 6 . 6 . 457–64 . June 2006 . 16691243 . 10.1038/nri1859 . 7915923 .
3. Visser N, Nelemans LC, He Y, Lourens HJ, Corrales MG, Huls G, Wiersma VR, Schuringa JJ, Bremer E . Signal regulatory protein beta 2 is a novel positive regulator of innate anticancer immunity . Frontiers in Immunology . 14 . 1287256 . December 2023 . 38116002 . 10.3389/fimmu.2023.1287256 . free .