Signal-recognition-particle GTPase explained

Signal-recognition-particle GTPase
Ec Number:	3.6.5.4

Signal-recognition-particle GTPase is an enzyme with systematic name GTP phosphohydrolase (protein-synthesis-assisting).^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

GTP + H₂O

\rightleftharpoons GDP + phosphate

Enzyme activity is associated with the signal-recognition particle.

See also

• Signal recognition particle

Notes and References

1. Connolly T, Gilmore R . The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide . Cell . 57 . 4 . 599–610 . May 1989 . 2541918 . 10.1016/0092-8674(89)90129-3 .
2. Connolly T, Rapiejko PJ, Gilmore R . Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor . Science . 252 . 5009 . 1171–3 . May 1991 . 1851576 . 10.1126/science.252.5009.1171 .
3. Miller JD, Wilhelm H, Gierasch L, Gilmore R, Walter P . GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation . Nature . 366 . 6453 . 351–4 . November 1993 . 8247130 . 10.1038/366351a0 .
4. Freymann DM, Keenan RJ, Stroud RM, Walter P . Structure of the conserved GTPase domain of the signal recognition particle . Nature . 385 . 6614 . 361–4 . January 1997 . 9002524 . 10.1038/385361a0 .