| Conflict: | Siege of Groenlo (1606) |
| Partof: | the Dutch Revolt |
| Date: | 3–14 August 1606 (Spinola) 30 October - 9 November 1606 (Maurice) |
| Place: | Groenlo, Gelderland (present-day the Netherlands) |
| Result: | 1st Siege: Spanish victory 2nd Siege: Spanish victory |
| Combatant1: |  Spain |
| Combatant2: | United Provinces |
| Commander1: | Ambrosio Spinola |
| Commander2: | Maurice of Nassau Diederik van Dort |
| Strength1: | 15,000 |
| Strength2: | 1,300-1,400 |
The siege of Groenlo was a siege of Groenlo or Grol in 1606 during the Dutch Revolt. It lasted from 3 to 14 August 1606 and ended in the city being captured from the United Provinces by a Spanish Empire force under Ambrosio Spinola. A few months later Prince Maurice attempted to retake the city but failed due to poor planning and an intervention by Spinola. Groenlo would remain in Spanish hands until another siege in 1627.