Chromosome 17 Explained

Length Bp:	84,276,897 bp (CHM13)
Genes:	1,124 (CCDS)
Type:	Autosome
Centromere Position:	Submetacentric^[1] (25.1 Mbp^[2])
Chr:	17
Ensembl Id:	17
Entrez Id:	17
Ncbi Id:	17
Ucsc Id:	17
Refseq Id:	NC_000017
Genbank Id:	CM000679

Chromosome 17 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 17 spans more than 84 million base pairs (the building material of DNA) and represents between 2.5 and 3% of the total DNA in cells.

Chromosome 17 contains the Homeobox B gene cluster.

Genes

Number of genes

The following are some of the gene count estimates of human chromosome 17. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). The most conservative estimate, from CCDS, represents a lower bound on the total number of human protein-coding genes.^[3]

Estimated by	Protein-coding genes	Non-coding RNA genes	Pseudogenes	Source	Release date
	1,124	—	—	^[4]	2016-09-08
HGNC	1,132	325	458	^[5]	2017-05-12
	1,184	1,199	535	^[6]	2017-03-29
	1,169	—	—	^[7]	2018-02-28
	1,199	757	566	^[8] ^[9] ^[10]	2017-05-19

Gene list

The following is a partial list of genes on human chromosome 17. For complete list, see the link in the infobox on the right.

The following are some of the genes and their corresponding Cytogenetic location on chromosome 17:

q-arm

Diseases and disorders

The following diseases are related to genes on chromosome 17:

• 17q12 microdeletion syndrome
• Koolen–de Vries syndrome
• Alexander disease
• Andersen–Tawil syndrome
• Aneurysmal bone cyst
• Bipolar disorder
• Birt–Hogg–Dubé syndrome
• Bladder cancer
• Breast cancer
• Bruck syndrome
• Campomelic dysplasia
• Canavan disease
• Cerebroretinal microangiopathy with calcifications and cysts
• Charcot–Marie–Tooth disease
• Chronic lymphocytic leukaemia, tp53
• Corticobasal degeneration
• Cystinosis
• Depression
• Ehlers–Danlos syndrome
• Epidermodysplasia verruciformis
• Frontotemporal dementia and parkinsonism linked to chromosome 17
• Galactosemia
• Glycogen storage disease type II (Pompe disease)
• Hereditary neuropathy with liability to pressure palsies
• Howel–Evans syndrome
• Li–Fraumeni syndrome
• Maturity onset diabetes of the young type 5
• Miller–Dieker syndrome
• Multiple synostoses syndrome
• Neurofibromatosis type I
• Nonsyndromic deafness
• Obsessive–compulsive disorder
• Osteogenesis imperfecta
• Potocki–Lupski syndrome
• Proximal symphalangism
• Sanfilippo syndrome
• Smith–Magenis syndrome
• Usher syndrome
• Very long-chain acyl-coenzyme A dehydrogenase deficiency
• Von Gierke's syndrome

Cytogenetic band

G-bands of human chromosome 17 in resolution 850 bphs^[11] ! Chr.! Arm^[12] ! Band^[13] ! ISCN
start^[14] ! ISCN
stop! Basepair
start! Basepair
stop! Stain^[15] ! Density

17	p	13.3	0	385			gneg
17	p	13.2	385	550			gpos	50
17	p	13.1	550	784			gneg
17	p	12	784	990			gpos	75
17	p	11.2	990	1499			gneg
17	p	11.1	1499	1664			acen
17	q	11.1	1664	1815			acen
17	q	11.2	1815	2104			gneg
17	q	12	2104	2255			gpos	50
17	q	21.1	2255	2461			gneg
17	q	21.2	2461	2599			gpos	25
17	q	21.31	2599	2874			gneg
17	q	21.32	2874	3025			gpos	25
17	q	21.33	3025	3176			gneg
17	q	22	3176	3383			gpos	75
17	q	23.1	3383	3451			gneg
17	q	23.2	3451	3658			gpos	75
17	q	23.3	3658	3781			gneg
17	q	24.1	3781	3850			gpos	50
17	q	24.2	3850	4001			gneg
17	q	24.3	4001	4166			gpos	75
17	q	25.1	4166	4400			gneg
17	q	25.2	4400	4510			gpos	25
17	q	25.3	4510	4950			gneg

References

• Gilbert F . Disease genes and chromosomes: disease maps of the human genome. Chromosome 17 . Genet Test . 1998 . 357–81 . 2 . 4 . 10464617 . 10.1089/gte.1998.2.357.
• Gene Card Website https://www.genecards.org/cgi-bin/carddisp.pl?gene=SCN4A

External links

• Web site: National Institutes of Health. Chromosome 17. Genetics Home Reference. 2017-05-06. 2007-06-30. https://web.archive.org/web/20070630182545/http://ghr.nlm.nih.gov/chromosome=17. dead.
• Web site: Chromosome 17. Human Genome Project Information Archive 1990–2003. 2017-05-06.

Notes and References

1. Book: Tom Strachan. Andrew Read. Human Molecular Genetics. 2 April 2010. Garland Science. 978-1-136-84407-2. 45.
2. Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last update 2014-06-03. Retrieved 2017-04-26.
3. Pertea M, Salzberg SL. Between a chicken and a grape: estimating the number of human genes. . Genome Biol . 2010 . 11 . 5 . 206 . 20441615 . 10.1186/gb-2010-11-5-206 . 2898077 . free .
4. Web site: Search results - 17[CHR] AND "Homo sapiens"[Organism] AND ("has ccds"[Properties] AND alive[prop]) - Gene . NCBI . CCDS Release 20 for Homo sapiens . 2016-09-08 . 2017-05-28.
5. Web site: Statistics & Downloads for chromosome 17 . HUGO Gene Nomenclature Committee . 2017-05-12 . 2017-05-19.
6. Web site: Chromosome 17: Chromosome summary - Homo sapiens . Ensembl Release 88 . 2017-03-29 . 2017-05-19.
7. Web site: Human chromosome 17: entries, gene names and cross-references to MIM . UniProt . 2018-02-28 . 2018-03-16.
8. Web site: Search results - 17[CHR] AND "Homo sapiens"[Organism] AND ("genetype protein coding"[Properties] AND alive[prop]) - Gene . NCBI . 2017-05-19 . 2017-05-20.
9. Web site: Search results - 9[CHR] AND "Homo sapiens"[Organism] AND (("genetype miscrna"[Properties] OR "genetype ncrna"[Properties] OR "genetype rrna"[Properties] OR "genetype trna"[Properties] OR "genetype scrna"[Properties] OR "genetype snrna"[Properties] OR "genetype snorna"[Properties]) NOT "genetype protein coding"[Properties] AND alive[prop]) - Gene . NCBI . 2017-05-19 . 2017-05-20.
10. Web site: Search results - 17[CHR] AND "Homo sapiens"[Organism] AND ("genetype pseudo"[Properties] AND alive[prop]) - Gene . NCBI . 2017-05-19 . 2017-05-20.
11. Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last update 2014-06-03. Retrieved 2017-04-26.
12. "p": Short arm; "q": Long arm.
13. For cytogenetic banding nomenclature, see article locus.
14. These values (ISCN start/stop) are based on the length of bands/ideograms from the ISCN book, An International System for Human Cytogenetic Nomenclature (2013). Arbitrary unit.
15. gpos: Region which is positively stained by G banding, generally AT-rich and gene poor; gneg: Region which is negatively stained by G banding, generally CG-rich and gene rich; acen Centromere. var: Variable region; stalk: Stalk.