Serine 3-dehydrogenase explained

serine 3-dehydrogenase
Ec Number:	1.1.1.276
Cas Number:	9038-55-5
Go Code:	0031132

In enzymology, a serine 3-dehydrogenase is an enzyme that catalyzes the chemical reaction

L-serine + NADP⁺

\rightleftharpoons 2-ammoniomalonate semialdehyde + NADPH + H⁺

Thus, the two substrates of this enzyme are L-serine and NADP⁺, whereas its 3 products are 2-ammoniomalonate semialdehyde, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is L-serine:NADP⁺ 3-oxidoreductase.

References

• Fujisawa H, Nagata S, Chowdhury EK, Matsumoto M, Misono H . 2002 . Cloning and sequencing of the serine dehydrogenase gene from Agrobacterium tumefaciens . Biosci. Biotechnol. Biochem. . 66 . 1137 - 9 . 12092831 . 10.1271/bbb.66.1137 . 5 . free .
• Chowdhury EK, Higuchi K, Nagata S, Misono H . 1997 . A novel NADP(+)-dependent serine dehydrogenase from Agrobacterium tumefaciens . Biosci. Biotechnol. Biochem. . 61 . 152 - 7 . 9028042 . 10.1271/bbb.61.152 . 1 . free .