Selenophosphate synthetase 1 explained

Selenide, water dikinase 1 is an enzyme that in humans is encoded by the SEPHS1 gene.^{[1] [2]}

This protein functions as an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Tamura T, Yamamoto S, Takahata M, etal . Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 46 . 16162–7 . 2004 . 15534230 . 10.1073/pnas.0406313101 . 528966 . 2004PNAS..10116162T . free .
• Stelzl U, Worm U, Lalowski M, etal . A human protein-protein interaction network: a resource for annotating the proteome. . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Saiki R, Nagata A, Kainou T, etal . Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans. . FEBS J. . 272 . 21 . 5606–22 . 2005 . 16262699 . 10.1111/j.1742-4658.2005.04956.x . 13735213 . free .
• Chung HJ, Yoon SI, Shin SH, etal . p53-Mediated enhancement of radiosensitivity by selenophosphate synthetase 1 overexpression. . J. Cell. Physiol. . 209 . 1 . 131–41 . 2006 . 16786570 . 10.1002/jcp.20714 . 24313890 .

Notes and References

1. Low SC . Harney JW . Berry MJ . Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis . J Biol Chem . 270 . 37 . 21659–64 . Oct 1995 . 7665581 . 10.1074/jbc.270.37.21659 . free .
2. Web site: Entrez Gene: SEPHS1 selenophosphate synthetase 1.