Selenium responsive proteins explained

Selenium responsive proteins within human biology, are the class of proteins sensitive to selenium, in healthy human beings, in cancer patients, in in-vivo models or in-vitro cell culture models.

The original gi accession (version) numbers have been updated to NCBI accession number and protein names updated accordingly.

Accession Number Common abbreviation Protein name Responsive in Selenium compound technique used source
Q08091 CNN1 TRAMP (prostate cancer mouse model) MSeC iTRAQ LC-MS/MS Zhang 2010 [1]
NP_035656 TAGLN TRAMP (prostate cancer mouse model) MSeC iTRAQ LC-MS/MS Zhang 2010
NP_033822 APOA1 TRAMP (prostate cancer mouse model) MSeC, MseA iTRAQ LC-MS/MS Zhang 2010
NP_038499 ANXA4 TRAMP (prostate cancer mouse model) MseA iTRAQ LC-MS/MS Zhang 2010
gi21071030 A1BG Alpha 1B-glycoprotein Selenium enriched yeast 2D DIGE LC-MS/MS Sinha 2010 [2]
gi4557871 TF Selenium enriched yeast 2D DIGE LC-MS/MS Sinha 2010
gi4502501 C4b Complement component 4B proprotein Selenium enriched yeast 2D DIGE LC-MS/MS Sinha 2010
NP_059086 SEMG1TRAMP DLP UPMSeA, MSeCiTRAQ LC-MS/MSZhang 2010
CAA47699 BGPG Biliary glycoproteinTRAMP DLP UPMSeA, MSeCiTRAQ LC-MS/MSZhang 2010
NP_780375 BASP1 TRAMP DLP UPMSeAiTRAQ LC-MS/MSZhang 2010
NP_031789 Cysteine-rich protein 1TRAMP DLP UPMSeAiTRAQ LC-MS/MSZhang 2010
NP_059067 HPX HemopexinTRAMP DLP UPMSeAiTRAQ LC-MS/MSZhang 2010
gi7305531 Seminal vesicle secretion 6TRAMP DLP UPMSeAiTRAQ LC-MS/MSZhang 2010
NP_780375 DMBTL_MOUSE TRAMP DLP UPMSeCiTRAQ LC-MS/MSZhang 2010
gi6755212Proteasome (prosome, macropain) 28 subunit, αTRAMP DLP UPMSeCiTRAQ LC-MS/MSZhang 2010
NP_035309 PSAPProsaposinTRAMP DLP UPMSeCiTRAQ LC-MS/MSZhang 2010
gi123794006FUSE-binding protein 2TRAMP DLP UPMSeCiTRAQ LC-MS/MSZhang 2010
gi84875537NucleolinTRAMP DLP UPMSeCiTRAQ LC-MS/MSZhang 2010
gi40254525Tropomyosin 3, gammaTRAMP DLP UPMSeCiTRAQ LC-MS/MSZhang 2010
NP_032775 NUCB1 Nucleobindin 1TRAMP DLP DOWNMSeCiTRAQ LC-MS/MSZhang 2010
gi94717635Progesterone receptor membrane componentTRAMP DLP DOWNMSeCiTRAQ LC-MS/MSZhang 2010
gi21704156Caldesmon 1TRAMP DLP DOWNMSeCiTRAQ LC-MS/MSZhang 2010
gi31980648ATP synthase, H+ transporting mitochondrial F1 complex βTRAMP DLP DOWNMSeCiTRAQ LC-MS/MSZhang 2010
gi10946574Creatine kinase, brainTRAMP DLP DOWNMSeCiTRAQ LC-MS/MSZhang 2010
gi94367355Similar to 60S ribosomal protein L5TRAMP DLP DOWNMSeCiTRAQ LC-MS/MSZhang 2010
gi31981520Pancreatic ribonucleaseTRAMP DLP DOWNMSeCiTRAQ LC-MS/MSZhang 2010
gi6754084Glutathione S-transferase, mu 1TRAMP DLP DOWNMSeCiTRAQ LC-MS/MSZhang 2010
gi6680121Glutathione S-transferase, μ 2TRAMP DLP DOWNMSeCiTRAQ LC-MS/MSZhang 2010
gi31981302Annexin A6TRAMP DLP DOWNMSeCiTRAQ LC-MS/MSZhang 2010
gi6678740LumicanTRAMP DLP DOWNMSeCiTRAQ LC-MS/MSZhang 2010
gi94403723Similar to Heat shock 70-kDa protein 1B (HSP70.1)TRAMP DLP DOWNMSeCiTRAQ LC-MS/MSZhang 2010
gi89574165Succinate dehydrogenase complex subunit ATRAMP DLP DOWNMSeAiTRAQ LC-MS/MSZhang 2010
gi70778915MoesinTRAMP DLP DOWNMSeAiTRAQ LC-MS/MSZhang 2010
gi6679567Polymerase I and transcript release factorTRAMP DLP DOWNMSeAiTRAQ LC-MS/MSZhang 2010
gi31791059Activated leukocyte cell adhesion moleculeTRAMP DLP DOWNMSeAiTRAQ LC-MS/MSZhang 2010
gi76779293Keratin 8TRAMP DLP DOWNMSeAiTRAQ LC-MS/MSZhang 2010
gi6671549Peroxiredoxin 6TRAMP DLP DOWNMSeAiTRAQ LC-MS/MSZhang 2010
gi6680836CalreticulinTRAMP DLP DOWNMSeAiTRAQ LC-MS/MSZhang 2010
NP_808579 TGM4 TRAMP DLP DOWNMSeAiTRAQ LC-MS/MSZhang 2010
gi8567372ProbasinTRAMP DLP DOWNMSeAiTRAQ LC-MS/MSZhang 2010
gi250654578-kDa glucose-regulated protein precursor (GRP 78)TRAMP DLP DOWNMSeAiTRAQ LC-MS/MSZhang 2010
gi7643979170-kDa glucose regulated protein GRP170TRAMP DLP DOWNMSeAiTRAQ LC-MS/MSZhang 2010
gi31542563DnaJ (Hsp40) homolog, subfamily C, member 3TRAMP DLP DOWNMSeAiTRAQ LC-MS/MSZhang 2010
gi71774133Peptidylprolyl isomerase B (PPI)TRAMP DLP DOWNMSeAiTRAQ LC-MS/MSZhang 2010
gi130232Protein disulfide isomerase b family, ERp57 subfamilyTRAMP DLP DOWNMSeAiTRAQ LC-MS/MSZhang 2010
gi129729Protein disulfide isomerase ERp59TRAMP DLP DOWNMSeAiTRAQ LC-MS/MSZhang 2010
gi86198316Protein disulfide isomerase associated 4TRAMP DLP DOWNMSeAiTRAQ LC-MS/MSZhang 2010
gi58037267Protein disulfide isomerase-associated 6TRAMP DLP DOWNMSeA, MSeCiTRAQ LC-MS/MSZhang 2010
gi6753010Anterior gradient 2TRAMP DLP DOWNMSeA, MSeCiTRAQ LC-MS/MSZhang 2010
gi42794267Experimental autoimmune prostatitis antigen 2TRAMP DLP DOWNMSeA, MSeCiTRAQ LC-MS/MSZhang 2010
gi31543942VinculinTRAMP DLP DOWNMSeA, MSeCiTRAQ LC-MS/MSZhang 2010
gi94387119PREDICTED: similar to heat shock protein 8TRAMP DLP DOWNMSeA, MSeCiTRAQ LC-MS/MSZhang 2010
gi6752952Actin, γ2, smooth muscle, entericTRAMP DLP DOWNMSeA, MSeCiTRAQ LC-MS/MSZhang 2010
gi94381948PREDICTED: similar to Fc fragment of IgG binding proteinTRAMP DLP DOWNMSeA, MSeCiTRAQ LC-MS/MSZhang 2010
gi6754482Keratin complex 1, acidic, gene 18TRAMP DLP DOWNMSeA, MSeCiTRAQ LC-MS/MSZhang 2010
gi5031777Healthy Human blood serumSelenium enriched yeast2D DIGE LC-MS/MSSinha 2010
NP_005134 HP Haptoglobin isoform 1 preproprotein Healthy Human blood serumSelenium enriched yeast2D DIGE LC-MS/MSSinha 2010
gi42716297CLUClusterin isoform 1 Healthy Human blood serumSelenium enriched yeast2D DIGE LC-MS/MSSinha 2010
gi17318569Keratin 1Healthy Human blood serumSelenium enriched yeast2D DIGE LC-MS/MSSinha 2010
gi4507725TransthyretinHealthy Human blood serumSelenium enriched yeast2D DIGE LC-MS/MSSinha 2010
gi21361198AATHealthy Human blood serumSelenium enriched yeast2D DIGE LC-MS/MSSinha 2010
gi4557287Angiotensin precursor Healthy Human blood serumSelenium enriched yeast2D DIGE LC-MS/MSSinha 2010
gi4502027Albumin precursorHealthy Human blood serumSelenium enriched yeast2D DIGE LC-MS/MSSinha 2010

Notes and References

  1. Zhang . J. . Wang . L. . Anderson . L. B. . Witthuhn . B. . Xu . Y. . Lu . J. . Proteomic Profiling of Potential Molecular Targets of Methyl-Selenium Compounds in the Transgenic Adenocarcinoma of Mouse Prostate Model . Cancer Prevention Research . 3 . 8 . 994–1006 . 2010 . 10.1158/1940-6207.CAPR-09-0261. 20647336 . free .
  2. Sinha . R.. Sinha . I.. Facompre . N.. Russell . S.. Somiari . R.. Richie Jr . J.. El-Bayoumy . K.. 2010. Selenium responsive proteins in sera of selenium-enriched yeast supplemented healthy African American and Caucasian men. Cancer Epidemiology, Biomarkers & Prevention. 19 . 9 . 2332–2340. 10.1158/1055-9965.EPI-10-0253. 20643827 . 3326597.

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