Selenide, water dikinase explained

selenide, water dikinase
Ec Number:	2.7.9.3
Go Code:	0004756

In enzymology, a selenide, water dikinase is an enzyme that catalyzes the chemical reaction

ATP + selenide + H₂O

\rightleftharpoons AMP + selenophosphate + phosphate

The 3 substrates of this enzyme are ATP, selenide, and H₂O, whereas its 3 products are AMP, selenophosphate, and phosphate.

This enzyme belongs to the family of transferases, to be specific, those transferring phosphorus-containing groups (phosphotransferases) with paired acceptors (dikinases). The systematic name of this enzyme class is ATP:selenide, water phosphotransferase. This enzyme is also called selenophosphate synthetase. This enzyme participates in selenoamino acid metabolism.

References

• Veres Z, Tsai L, Scholz TD, Politino M, Balaban RS, Stadtman TC . 1992 . Synthesis of 5-methylaminomethyl-2-selenouridine in tRNAs: 31P NMR studies show the labile selenium donor synthesized by the selD gene product contains selenium bonded to phosphorus . Proc. Natl. Acad. Sci. U.S.A. . 89 . 2975 - 9 . 1557403 . 10.1073/pnas.89.7.2975 . 7 . 48786 . 1992PNAS...89.2975V . free .