Androgen receptor degrader explained

A (selective) androgen receptor degrader or downregulator (SARD) is a type of drug which interacts with the androgen receptor (AR) such that it causes the AR to be degraded and thus downregulated.^[1] They are under investigation for the treatment of prostate cancer and other androgen-dependent conditions.

As of 2017, dimethylcurcumin (ASC-J9), a SARD, is under development for the treatment of acne vulgaris.^[2]

See also

• Androgen deprivation therapy

Notes and References

1. Lai AC, Crews CM . Induced protein degradation: an emerging drug discovery paradigm . Nature Reviews. Drug Discovery . 16 . 2 . 101–114 . February 2017 . 27885283 . 5684876 . 10.1038/nrd.2016.211 .
2. Web site: ASCJ 9 . AdisInsight . Springer Nature Switzerland AG .