Securinine Explained

Securinine is an alkaloid found in Securinega suffruticosa^[1] and Phyllanthus niruri.^[2]

Pharmacology

Securinine has pro-convulsant effects^{[3] [4]} and it has a strong spastic effect, similar to the actions of strychnine.^[5]

Securinine is a GABA-_A antagonist.^{[6] [7]}

See also

• Norsecurinine
• Phenazine

Notes and References

1. Book: Du GH, Wang DS, Fang LH, Du GH . Natural Small Molecule Drugs from Plants . vanc . Securinine . Springer Singapore . 2018 . 978-981-10-8021-0 . 10.1007/978-981-10-8022-7_54 . 325–330.
2. Patel JR, Tripathi P, Sharma V, Chauhan NS, Dixit VK . Phyllanthus amarus: ethnomedicinal uses, phytochemistry and pharmacology: a review . Journal of Ethnopharmacology . 138 . 2 . 286–313 . November 2011 . 21982793 . 10.1016/j.jep.2011.09.040 .
3. Tao SC, Peng JZ, Lu MW . [Central convulsive action of l-securinine] . Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica . 7 . 1 . 9–12 . January 1986 . 2876581 .
4. Zhang SC, Li SZ, Gao XC, Qian LH, Yang MZ, Yuan HN, Tan DJ . [The adverse effects of the preparations of the active principles of Chinese herbal drugs] . Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica . 18 . 7 . 387–391 . July 1993 . 8267848 .
5. Klochkov S, Neganova M . Unique indolizidine alkaloid securinine is a promising scaffold for the development of neuroprotective and antitumor drugs . RSC Advances . 11 . 31 . 19185–19195 . May 2021 . 35478659 . 9033663 . 10.1039/D1RA02558A . free . 2021RSCAd..1119185K .
6. Web site: Securinine. PubChem, US National Library of Medicine. 2020-07-04.
7. Beutler JA, Karbon EW, Brubaker AN, Malik R, Curtis DR, Enna SJ . Securinine alkaloids: a new class of GABA receptor antagonist . Brain Research . 330 . 1 . 135–140 . March 1985 . 2985189 . 10.1016/0006-8993(85)90014-9 . 21138482 .