Secologanin synthase explained

secologanin synthase
Ec Number:	1.14.19.62
Cas Number:	258339-71-8
Go Code:	0050616

In enzymology, a secologanin synthase (was wrongly classified as in the past) is an enzyme that catalyzes the chemical reaction

loganin + NADPH + H⁺ + O₂

\rightleftharpoons secologanin + NADP⁺ + 2 H₂O

The 4 substrates of this enzyme are loganin, NADPH, H⁺, and O₂, whereas its 3 products are secologanin, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with oxygen as acceptor. The systematic name of this enzyme class is loganin:oxygen oxidoreductase (ring-cleaving). This enzyme participates in indole and ipecac alkaloid biosynthesis.

References

• Yamamoto H, Katano N, Ooi A, Inoue K . 2000 . Secologanin synthase which catalyzes the oxidative cleavage of loganin into secologanin is a cytochrome P450 . . 53 . 7 - 12 . 10656401 . 10.1016/S0031-9422(99)00471-9 . 1 .
• Strack D, Matern U, Schroder J . 2000 . Indole alkaloid biosynthesis in Catharanthus roseus: new enzyme activities and identification of cytochrome P450 CYP72A1 as secologanin synthase . Plant J. . 24 . 797 - 804 . 11135113 . 10.1046/j.1365-313x.2000.00922.x . 6 .
• Yamamoto H, Katano N, Ooi Y, Inoue K . 1999 . Transformation of loganin and 7-deoxyloganin into secologanin by Lonicera japonica cell suspension cultures . . 50 . 3 . 417 - 422 . 10.1016/S0031-9422(98)00613-X .