Secoisolariciresinol dehydrogenase explained

Secoisolariciresinol dehydrogenase
Ec Number:	1.1.1.331

Secoisolariciresinol dehydrogenase is an enzyme with the systematic name (-)-secoisolariciresinol:NAD⁺ oxidoreductase.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction:

(-)-secoisolariciresinol + 2 NAD+

\rightleftharpoons (-)-matairesinol + 2 NADH + 2 H+

This enzyme is isolated from the plants Forsythia intermedia and Podophyllum peltatum.

Notes and References

1. Xia ZQ, Costa MA, Pelissier HC, Davin LB, Lewis NG . Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection . The Journal of Biological Chemistry . 276 . 16 . 12614–23 . April 2001 . 11278426 . 10.1074/jbc.M008622200 . free .
2. Youn B, Moinuddin SG, Davin LB, Lewis NG, Kang C . Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans . The Journal of Biological Chemistry . 280 . 13 . 12917–26 . April 2005 . 15653677 . 10.1074/jbc.M413266200 . free .
3. Moinuddin SG, Youn B, Bedgar DL, Costa MA, Helms GL, Kang C, Davin LB, Lewis NG . Secoisolariciresinol dehydrogenase: mode of catalysis and stereospecificity of hydride transfer in Podophyllum peltatum . Organic & Biomolecular Chemistry . 4 . 5 . 808–16 . March 2006 . 16493463 . 10.1039/b516563f .