Secoisolariciresinol Explained

Secoisolariciresinol is an organic compound. It is classified as a lignan, i.e., a type of phenylpropanoid. It is present in some cereals, such as rye, and together with matairesinol has attracted much attention for its beneficial nutritional effects.

Occurrence

The water extract of silver fir wood contains more than 5% of secoisolariciresinol.[1] It is also present in nettle brew.[2] Its content in flaxseed (Linum usitatissimum) was found to be 0.3%,[3] which is the highest known content in food.

Biomedical aspects

In the intestine the gut microflora can form secoisolariciresinol from the secoisolariciresinol diglucoside and it can then be further transformed into the enterolignan enterodiol. Epidemiological studies showed associations between secoisolariciresinol intake and decreased risk of cardiovascular disease are promising, but they are yet not well established, perhaps due to low lignan intakes in habitual Western diets. At the higher doses used in intervention studies, associations were more evident.[4] [5]

Glycosides

Notes and References

  1. 10.1080/02773813.2017.1340958. Identification, in vitro and in vivo Antioxidant Activity, and Gastrointestinal Stability of Lignans from Silver Fir (Abies alba) Wood Extract. Journal of Wood Chemistry and Technology. 37. 6. 467. 2017. Tavčar Benković. Eva. Žigon. Dušan. Mihailović. Vladimir. Petelinc. Tanja. Jamnik. Polona. Kreft. Samo. 90833072.
  2. Francišković. Marina. Gonzalez-Pérez. Raquel. Orčić. Dejan. Sánchez de Medina. Fermín. Martínez-Augustin. Olga. Svirčev. Emilija. Simin. Nataša. Mimica-Dukić. Neda. August 2017. Chemical Composition and Immuno-Modulatory Effects of Urtica dioica L. (Stinging Nettle) Extracts. Phytotherapy Research. 31. 8. 1183–1191. 10.1002/ptr.5836. 1099-1573. 28544187. 33903986.
  3. Milder. Ivon E. J.. Arts. Ilja C. W.. Putte. Betty van de. Venema. Dini P.. Hollman. Peter C. H.. 2005. Lignan contents of Dutch plant foods: a database including lariciresinol, pinoresinol, secoisolariciresinol and matairesinol. British Journal of Nutrition. en. 93. 3. 393–402. 10.1079/bjn20051371. 1475-2662. 15877880. free.
  4. Peterson. Julia. Dwyer. Johanna. Adlercreutz. Herman. Scalbert. Augustin. Jacques. Paul. McCullough. Marjorie L.. 2010-10-01. Dietary lignans: physiology and potential for cardiovascular disease risk reduction. Nutrition Reviews. en. 68. 10. 571–603. 10.1111/j.1753-4887.2010.00319.x. 20883417. 0029-6643. 2951311.
  5. Pan. An. Yu. Danxia. Demark-Wahnefried. Wendy. Franco. Oscar H. Lin. Xu. 2009-08-01. Meta-analysis of the effects of flaxseed interventions on blood lipids. The American Journal of Clinical Nutrition. en. 90. 2. 288–297. 10.3945/ajcn.2009.27469. 19515737. 0002-9165. 3361740.

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