Scytalone dehydratase explained

scytalone dehydratase
Ec Number:	4.2.1.94
Go Code:	0030411

The enzyme scytalone dehydratase catalyzes the chemical reaction

\rightleftharpoons 1,3,8-trihydroxynaphthalene + H₂O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming). This enzyme is also called scytalone 7,8-hydro-lyase.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,, and .

References

• Butler MJ, Lazarovits G, Higgins VJ, Lachance MA . 1988 . Partial-purification and characterization of a dehydratase associated with the pentaketide melanogenesis pathway of Phaeococcomyces sp and other fungi . Exp. Mycol. . 12 . 4 . 367 - 376 . 10.1016/0147-5975(88)90028-X .
• Tajima S, Kubo Y, Furusawa I, Shishiyama J . 1989 . Purification of a melanin biosynthetic enzyme converting scytalone to 1,3,8-trihydroxynaphthalene from Cochliobolus miyabeanus . Exp. Mycol. . 13 . 69–76 . 10.1016/0147-5975(89)90009-1 .
• Wheeler MH . Greenblatt GA . 1988 . The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease . Exp. Mycol. . 12 . 2 . 151 - 160 . 10.1016/0147-5975(88)90004-7 .