Scytalidopepsin A Explained

Scytalidopepsin A
Ec Number:	3.4.23.31
Cas Number:	42613-34-3

Scytalidopepsin A (Scytalidium aspartic proteinase A, Scytalidium lignicolum aspartic proteinase, Scytalidium lignicolum aspartic proteinase A-2, Scytalidium lignicolum aspartic proteinase A-I, Scytalidium lignicolum aspartic proteinase C, Scytalidium lignicolum carboxyl proteinase, Scytalidium lignicolum acid proteinase) is an enzyme.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

Hydrolysis of proteins with specificity similar to that of pepsin A, but also cleaves Cys(SO₃H)⁷-Gly and Leu¹⁷-Val in the B chain of insulin

This enzyme is isolated from the fungus Scytalidium lignicolum.

Notes and References

1. Purification and some enzymatic properties of acid protease A and B of Scytalidium lignicolum ATCC 24568 . Oda K, Murao S . Agric. Biol. Chem. . 1974 . 38 . 2435–2444 . 10.1271/bbb1961.38.2435. free .
2. Action of Scytalidium lignicolum acid proteases on insulin B-chain . Oda K, Murao S . Agric. Biol. Chem. . 1976 . 40 . 1221–1225 . 10.1271/bbb1961.40.1221. free .
3. Purification and characterization of acid proteinase C of Scytalidium lignicolum ATCC 24568 . Oda K, Torishima H, Murao S . Agric. Biol. Chem. . 1986 . 50 . 651–658 . 10.1271/bbb1961.50.651. free .