Scavenger receptor cysteine-rich protein domain explained

Symbol:	SRCR
SRCR
Pfam:	PF00530
Interpro:	IPR001190
Prosite:	PDOC00348
Scop:	1by2

In molecular biology, the protein domain SRCR is short for Scavenger receptor cysteine-rich domain. They are found solely in eukaryotes.These domains are present on the cell membrane and have a role in binding to specific ligands and are often found to be involved with the immune system.^[1]

Function

The function of these endocytic receptors are to mediating non-opsonic phagocytosis in response to foreign ligands. This triggers various processes of host defence and immune response.^[2]

Structure

The structure contains a six stranded beta-sheet and one alpha-helix.^[1]

Examples

The speract receptor found in egg, is a transmembrane glycoprotein.^[3] Other members of this family include the macrophage scavenger receptor type I, an enteropeptidase, and T-cell surface glycoprotein CD5.

Notes and References

1. Hohenester E . Sasaki T . Timpl R . Crystal structure of a scavenger receptor cysteine-rich domain sheds light on an ancient superfamily. . Nat Struct Biol . 1999 . 6 . 3 . 228–32 . 10074941 . 10.1038/6669 . 5915649 .
2. Liu L, Yang J, Qiu L, Wang L, Zhang H, Wang M, etal . A novel scavenger receptor-cysteine-rich (SRCR) domain containing scavenger receptor identified from mollusk mediated PAMP recognition and binding. . Dev Comp Immunol . 2011 . 35 . 2 . 227–39 . 20888856 . 10.1016/j.dci.2010.09.010 .
3. Resnick D . Pearson A . Krieger M . The SRCR superfamily: a family reminiscent of the Ig superfamily . Trends Biochem. Sci. . 19 . 1 . 5–8 . January 1994 . 8140623 . 10.1016/0968-0004(94)90165-1.