Sauvagine Explained

Sauvagine
Organism:	Phyllomedusa sauvagei
Taxid:	8395
Symbol:	N/A
Cas Number:	74434-59-6
Uniprot:	P01144

Sauvagine is a neuropeptide from the corticotropin-releasing factor (CRF) family of peptides and is orthologous to the mammalian hormone, urocortin 1, and the teleost fish hormone, urotensin 1.^[1] It is 40 amino acids in length,^[2] and has the sequence XGPPISIDLSLELLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2, with a pyrrolidone carboxylic acid modification at the N-terminal and amidation of the C-terminal isoleucine residue. It was originally isolated from the skin of the frog Phyllomedusa sauvagii. Given its relation to other CRF-related peptides, it exerts similar physiological effects as corticotropin-releasing hormone.^{[3] [4]}

Sauvagine belongs to the corticotropin-releasing factor (CRF) family that also includes CRF, urocortin l/urotensin l, urocortin II and urocortin III.^[5]

Interactions

Sauvagine has been shown to interact with corticotropin releasing factor receptors 1 and 2, and (as with other CRF-related peptides) is also bound by the corticotropin-releasing factor binding protein.^[6]

Notes and References

1. Lovejoy DA, de Lannoy L . 24576375 . Evolution and phylogeny of the corticotropin-releasing factor (CRF) family of peptides: expansion and specialization in the vertebrates . Journal of Chemical Neuroanatomy . 54 . 50–6 . December 2013 . 24076419 . 10.1016/j.jchemneu.2013.09.006 .
2. Montecucchi PC, Henschen A . Amino acid composition and sequence analysis of sauvagine, a new active peptide from the skin of Phyllomedusa sauvagei . International Journal of Peptide and Protein Research . 18 . 2 . 113–20 . August 1981 . 7309372 . 10.1111/j.1399-3011.1981.tb02047.x.
3. Falaschi P, D'Urso R, Negri L, Rocco A, Montecucchi PC, Henschen A, Melchiorri P, Erspamer V . Potent in vivo and in vitro prolactin inhibiting activity of sauvagine, a frog skin peptide . Endocrinology . 111 . 2 . 693–5 . August 1982 . 7094889 . 10.1210/endo-111-2-693 .
4. Brown MR, Fisher LA, Spiess J, Rivier J, Rivier C, Vale W . 22063430 . Comparison of the biologic actions of corticotropin-releasing factor and sauvagine . Regulatory Peptides . 4 . 2 . 107–14 . July 1982 . 6289384 . 10.1016/0167-0115(82)90101-X .
5. Fekete EM, Zorrilla EP . Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: ancient CRF paralogs . Frontiers in Neuroendocrinology . 28 . 1 . 1–27 . April 2007 . 17083971 . 2730896 . 10.1016/j.yfrne.2006.09.002 .
6. Jahn O, Eckart K, Sydow S, Hofmann BA, Spiess J . 45722298 . Pharmacological characterization of recombinant rat corticotropin releasing factor binding protein using different sauvagine analogs . Peptides . 22 . 1 . 47–56 . January 2001 . 11179597 . 10.1016/S0196-9781(00)00356-9 .