S-SodF RNA explained

SodF sRNA
Rfam:	RF02790
Tax Domain:	Bacteria
Go:	,,

s-SodF RNA is a non-coding RNA (ncRNA) molecule identified in Streptomyces coelicolor. It is produced from sodF mRNA by cleavage of about 90 nucleotides from its 3′UTR. However it does not affect the function of sodF mRNA, but It acts on another mRNA called sodN. s-SodF RNA has a sequence complementary to sodN mRNA from the 5′-end up to the ribosome binding site. It pairs with sodN mRNA, blocks its translation and facilitates sodN mRNA decay.^[1] In Streptomyces sodF and sodN genes produce FeSOD and NiSOD superoxide dismutases containing Fe and Ni respectively. Their expression is inversely regulated by nickel-specific Fur-family regulator called Nur. When Ni is present Nur directly represses sodF transcription, and indirectly induces sodN.^{[2] [3] [4] [5] [6]}

Notes and References

1. Kim HM, Shin JH, Cho YB, Roe JH . Inverse regulation of Fe- and Ni-containing SOD genes by a Fur family regulator Nur through small RNA processed from 3′UTR of the sodF mRNA . Nucleic Acids Research . 42 . 3 . 2003–2014 . February 2014 . 24234448 . 3919588 . 10.1093/nar/gkt1071 .
2. Kim EJ, Chung HJ, Suh B, Hah YC, Roe JH . Expression and regulation of the sodF gene encoding iron- and zinc-containing superoxide dismutase in Streptomyces coelicolor Müller . Journal of Bacteriology . 180 . 8 . 2014–2020 . April 1998 . 10.1128/JB.180.8.2014-2020.1998 . 9555880 . 107124.
3. Kim EJ, Chung HJ, Suh B, Hah YC, Roe JH . Transcriptional and post-transcriptional regulation by nickel of sodN gene encoding nickel-containing superoxide dismutase from Streptomyces coelicolor Müller . Molecular Microbiology . 27 . 1 . 187–195 . January 1998 . 9466266 . 10.1046/j.1365-2958.1998.00674.x. 19859523 . free .
4. Ahn BE, Cha J, Lee EJ, Han AR, Thompson CJ, Roe JH . Nur, a nickel-responsive regulator of the Fur family, regulates superoxide dismutases and nickel transport in Streptomyces coelicolor . Molecular Microbiology . 59 . 6 . 1848–1858 . March 2006 . 16553888 . 10.1111/j.1365-2958.2006.05065.x . 2728024 . free .
5. An YJ, Ahn BE, Han AR, Kim HM, Chung KM, Shin JH, Cho YB, Roe JH, Cha SS . Structural basis for the specialization of Nur, a nickel-specific Fur homolog, in metal sensing and DNA recognition . Nucleic Acids Research . 37 . 10 . 3442–3451 . June 2009 . 19336416 . 2691836 . 10.1093/nar/gkp198 .
6. Chung HJ, Choi JH, Kim EJ, Cho YH, Roe JH . Negative regulation of the gene for Fe-containing superoxide dismutase by an Ni-responsive factor in Streptomyces coelicolor . Journal of Bacteriology . 181 . 23 . 7381–7384 . December 1999 . 10.1128/JB.181.23.7381-7384.1999 . 10572144 . 103703.