Ryanodine receptor 3 explained

Ryanodine receptor 3 is one of a class of ryanodine receptors and a protein that in humans is encoded by the RYR3 gene.^[1] The protein encoded by this gene is both a calcium channel and a receptor for the plant alkaloid ryanodine. RYR3 and RYR1 control the resting calcium ion concentration in skeletal muscle.^[2]

See also

• Ryanodine receptor

Further reading

• Bertocchini F . Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles . EMBO J. . 16 . 23 . 6956–63 . 1997 . 9384575 . 10.1093/emboj/16.23.6956 . 1170299 . vanc. Ovitt CE . Conti A . 3 . Barone . V . Schöler . HR . Bottinelli . R . Reggiani . C . Sorrentino . V .
• Bultynck G . Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor . Biochem. J. . 354 . Pt 2 . 413–22 . 2001 . 11171121 . 10.1042/bj3540413 . 1221670 . vanc. De Smet P . Rossi D . 3 . Callewaert . Geert . Missiaen . Ludwig . Sorrentino . Vincenzo . De Smedt . Humbert . Parys . Jan B. .
• Schwarzmann N . Knock-down of the type 3 ryanodine receptor impairs sustained Ca2+ signaling via the T cell receptor/CD3 complex . J. Biol. Chem. . 277 . 52 . 50636–42 . 2002 . 12354756 . 10.1074/jbc.M209061200 . vanc. Kunerth S . Weber K . 3 . . free .
• Nakashima Y . Molecular cloning and characterization of a human brain ryanodine receptor . FEBS Lett. . 417 . 1 . 157–62 . 1997 . 9395096 . 10.1016/S0014-5793(97)01275-1 . vanc. Nishimura S . Maeda A . 3 . . 21591492 .
• Xiao B . Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors) . J. Biol. Chem. . 277 . 44 . 41778–85 . 2002 . 12213830 . 10.1074/jbc.M208210200 . vanc. Masumiya H . Jiang D . 3 . . free .
• Davis MR . Principal mutation hotspot for central core disease and related myopathies in the C-terminal transmembrane region of the RYR1 gene . Neuromuscul. Disord. . 13 . 2 . 151–7 . 2003 . 12565913 . 10.1016/S0960-8966(02)00218-3 . vanc. Haan E . Jungbluth H . 3 . Sewry . C . North . K . Muntoni . F . Kuntzer . T . Lamont . P . Bankier . A . 30235519 .
• Kitahara K . Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients . Dis. Markers . 25 . 3 . 175–80 . 2008 . 19096130 . 3827802 . 10.1155/2008/426764. vanc. Kawa S . Katsuyama Y . 3 . . free .
• Tochigi M . No association between the ryanodine receptor 3 gene and autism in a Japanese population . Psychiatry Clin. Neurosci. . 62 . 3 . 341–4 . 2008 . 18588595 . 10.1111/j.1440-1819.2008.01802.x . vanc. Kato C . Ohashi J . 3 . Koishi . Shinko . Kawakubo . Yuki . Yamamoto . Kenji . Matsumoto . Hideo . Hashimoto . Ohiko . Kim . Soo-Yung . free .
• Masumiya H . The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors . FEBS Lett. . 553 . 1–2 . 141–4 . 2003 . 14550562 . 10.1016/S0014-5793(03)00999-2 . vanc. Yamamoto H . Hemberger M . 3 . Tanaka . H . Shigenobu . K . Chen . SR . Furukawa . T . 2003FEBSL.553..141M . 20575812 .
• Jiang D, Xiao B, Li X, Chen SR . Smooth muscle tissues express a major dominant negative splice variant of the type 3 Ca2+ release channel (ryanodine receptor) . J. Biol. Chem. . 278 . 7 . 4763–9 . 2003 . 12471029 . 10.1074/jbc.M210410200 . free .
• Mohaupt MG . Association between statin-associated myopathy and skeletal muscle damage . Canadian Medical Association Journal . 181 . 1–2 . E11–8 . 2009 . 19581603 . 10.1503/cmaj.081785 . 2704421 . vanc. Karas RH . Babiychuk EB . 3 . Sanchez-Freire . V. . Monastyrskaya . K. . Iyer . L. . Hoppeler . H. . Breil . F. . Draeger . A. .
• Balschun D . Deletion of the ryanodine receptor type 3 (RyR3) impairs forms of synaptic plasticity and spatial learning . EMBO J. . 18 . 19 . 5264–73 . 1999 . 10508160 . 10.1093/emboj/18.19.5264 . 1171597 . vanc. Wolfer DP . Bertocchini F . 3 . .
• Martin C, Chapman KE, Seckl JR, Ashley RH . Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum . Neuroscience . 85 . 1 . 205–16 . 1998 . 9607712 . 10.1016/S0306-4522(97)00612-X . 25634042 .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Van Acker K . The 12 kDa FK506-binding protein, FKBP12, modulates the Ca(2+)-flux properties of the type-3 ryanodine receptor . J. Cell Sci. . 117 . Pt 7 . 1129–37 . 2004 . 14970260 . 10.1242/jcs.00948 . vanc. Bultynck G . Rossi D . 3 . . free .
• Bultynck G . The conserved sites for the FK506-binding proteins in ryanodine receptors and inositol 1,4,5-trisphosphate receptors are structurally and functionally different . J. Biol. Chem. . 276 . 50 . 47715–24 . 2001 . 11598113 . 10.1074/jbc.M106573200 . vanc. Rossi D . Callewaert G . 3 . Missiaen . L . Sorrentino . V . Parys . JB . De Smedt . H . free .
• Leeb T, Brenig B . cDNA cloning and sequencing of the human ryanodine receptor type 3 (RYR3) reveals a novel alternative splice site in the RYR3 gene . FEBS Lett. . 423 . 3 . 367–70 . 1998 . 9515741 . 10.1016/S0014-5793(98)00124-0 . 1998FEBSL.423..367L . 19974365 .
• Lynn S . Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle . FEBS Lett. . 372 . 1 . 6–12 . 1995 . 7556644 . 10.1016/0014-5793(95)00924-X . vanc. Morgan JM . Lamb HK . 3 . Meissner . G . Gillespie . JI . 41319934 . free. 1995FEBSL.372....6L .

Notes and References

1. Sorrentino V, Giannini G, Malzac P, Mattei MG . Localization of a novel ryanodine receptor gene (RYR3) to human chromosome 15q14-q15 by in situ hybridization . Genomics . 18 . 1 . 163–5 . Feb 1994 . 8276408 . 10.1006/geno.1993.1446 .
2. Perez CF, López JR, Allen PD . Expression levels of RyR1 and RyR3 control resting free Ca2+ in skeletal muscle . Am. J. Physiol., Cell Physiol. . 288 . 3 . C640–9 . March 2005 . 15548569 . 10.1152/ajpcell.00407.2004 . 30888541 .