Russellysin Explained

Russellysin
Ec Number:3.4.24.58
Cas Number:79393-92-3

Russellysin (Russell's viper venom factor X activator, RVV-X, blood-coagulation factor X activating enzyme, metalloproteinase RVV-x, Vipera russelli proteinase, Russell's viper blood coagulation factor X activator, RVV-V) is an enzyme.[1] [2] [3] This enzyme catalyses the following chemical reaction

Specifically activates several components of the blood clotting system, including coagulation factor X, coagulation factor IX and protein C by cleavage of -Arg- bonds. Has no action on insulin B chain

This enzyme is present in the venom of Russell's viper (Vipera russelli).

Notes and References

  1. Book: Furie BC, Furie B . Coagulant protein of Russell's viper venom . Part B: Proteolytic Enzymes . Methods in Enzymology . 45 . 191–205 . 1976 . 1011991 . 10.1016/s0076-6879(76)45019-x . 978-0-12-181945-3 .
  2. Lindquist PA, Fujikawa K, Davie EW . Activation of bovine factor IX (Christmas factor) by factor XIa (activated plasma thromboplastin antecedent) and a protease from Russell's viper venom . The Journal of Biological Chemistry . 253 . 6 . 1902–9 . March 1978 . 10.1016/S0021-9258(19)62334-3 . free . 632245 .
  3. Takeya H, Nishida S, Miyata T, Kawada S, Saisaka Y, Morita T, Iwanaga S . Coagulation factor X activating enzyme from Russell's viper venom (RVV-X). A novel metalloproteinase with disintegrin (platelet aggregation inhibitor)-like and C-type lectin-like domains . The Journal of Biological Chemistry . 267 . 20 . 14109–17 . July 1992 . 10.1016/S0021-9258(19)49685-3 . free . 1629211 .

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