Rubredoxin—NAD(+) reductase explained

rubredoxin-NAD^+ reductase
Ec Number:	1.18.1.1
Cas Number:	9032-27-3
Go Code:	0015044

In enzymology, a rubredoxin-NAD⁺ reductase is an enzyme that catalyzes the chemical reaction.

2 reduced rubredoxin + NAD⁺ + H⁺

\rightleftharpoons 2 oxidized rubredoxin + NADH

The 3 substrates of this enzyme are reduced rubredoxin, NAD⁺, and H⁺, whereas its two products are oxidized rubredoxin and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on iron-sulfur proteins as donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is rubredoxin:NAD⁺ oxidoreductase. Other names in common use include rubredoxin reductase, rubredoxin-nicotinamide adenine dinucleotide reductase, dihydronicotinamide adenine dinucleotide-rubredoxin reductase, reduced nicotinamide adenine dinucleotide-rubredoxin reductase, NADH-rubredoxin reductase, rubredoxin-NAD reductase, NADH: rubredoxin oxidoreductase, DPNH-rubredoxin reductase, and NADH-rubredoxin oxidoreductase. This enzyme participates in fatty acid metabolism. It has 2 cofactors: FAD and Iron.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

See also

• Rubredoxin—NAD(P)(+) reductase

References

• Peterson JA, Kusunose M, Kusunose E, Coon MJ . 1967 . Enzymatic omega-oxidation. II. Function of rubredoxin as the electron carrier in omega-hydroxylation . J. Biol. Chem. . 242 . 4334 - 40 . 4294330 . 19 .
• 1972 . Enzymatic -oxidation. VI. Isolation of homogeneous reduced diphosphopyridine nucleotide-rubredoxin reductase . J. Biol. Chem. . 247 . 2109 - 16 . 4335861 . 7 .
• Ueda T, Coon MJ . 1972 . Enzymatic oxidation. VII. Reduced diphosphopyridine nucleotide-rubredoxin reductase: properties and function as an electron carrier in hydroxylation . J. Biol. Chem. . 247 . 5010 - 6 . 4403503 . 16 .
• Petitdemange H, Marczak R, Blusson H, Gay R . 1979 . Isolation and properties of reduced nicotinamide adenine dinucleotiderubredoxin oxidoreductase of Clostridium acetobutylicum . Biochem. Biophys. Res. Commun. . 91 . 1258 - 65 . 526302 . 10.1016/0006-291X(79)91202-6 . 4 .