Rubratoxin Explained

Rubratoxins are hepatotoxic mycotoxin produced by Penicillium rubrum and Penicillium purpurogenum. Rubratoxin A and rubratoxin B have been known since 1950s.[1] Rubratoxins are also known as protein phosphatase 2A (PP2A) specific inhibitor. The PP2A inhibitory activity of rubratoxin A is about 100-fold higher than rubratoxin B [2] and rubratoxin A is now used as a chemical probe for PP2A research.[3]

Notes and References

  1. Chen. Ri-Dao. Yan. Zheng. Zou. Jian-Hua. Wang. Nan. Dai. Jun-Gui. 2014-09-01. Rubratoxin C, a new nonadride derivative from an endophytic fungus Penicillium sp. F-14. Chinese Chemical Letters. 25. 9. 1308–1310. 10.1016/j.cclet.2014.03.040.
  2. Wada. Shun-ichi. Usami. Ihomi. Umezawa. Yoji. Inoue. Hiroyuki. Ohba. Shun-ichi. Someno. Tetsuya. Kawada. Manabu. Ikeda. Daishiro. 2010-03-01. Rubratoxin A specifically and potently inhibits protein phosphatase 2A and suppresses cancer metastasis. Cancer Science. 101. 3. 743–750. 10.1111/j.1349-7006.2009.01438.x. 1349-7006. 20028386. free. 11158319.
  3. 10.1021/cr050029r . Natural Products with Maleic Anhydride Structure: Nonadrides, Tautomycin, Chaetomellic Anhydride, and Other Compounds . 2007 . Chen . Xiaolong . Zheng . Yuguo . Shen . Yinchu . Chemical Reviews . 107 . 5 . 1777–1830 . 17439289 .

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