Rs5569 Explained

Rsid:5569
Name 1:A1287G
Name 2:G1287A
Gene:SLC6A2
Region:Exon 9
Chromosome:16

In genetics, rs5569 (A1287G or G1287A) is a genetic variant.It is a single nucleotide polymorphism (SNP) in the SLC6A2 gene in exon 9.This gene codes the norepinephrine transporter.The SNP is a silent substitution andthe nucleotides of both variants code a threonine amino acid.[1]

Several research studies have examined the effect of the variant in relation to alcohol dependence,[2] [3] attention deficit hyperactivity disorder,[4] diabetes,[5] major depressive disorder,[6] [7] panic disorder,[8] Tourette syndrome[9] and personality traits.[10] None of the studies have found an association.

References

Further reading

Notes and References

  1. https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?chooseRs=het&locusId=6530&mrna=NM_001043.2&ctg=NT_010498.15&prot=NP_001034.1&orien=forward&refresh=refresh dbSNP
  2. Jerzy Samochowiec, Jolanta Kucharska-Mazur, Ryszard Kaminski, Michael Smolka, Hans Rommelschpacher, Catrin Wernicke, Agnieszka Tymicz & Lutz Gerhardt Schmidt . Norepinephrine transporter gene polymorphism is not associated with susceptibility to alcohol dependence . . 111 . 2–3 . 229–33 . August 2002 . 12374639 . 10.1016/S0165-1781(02)00145-2. 6493515 .
  3. San-Yuan Huang, Ru-Band Lu, Kuo-Hsing Ma, Mee-Jen Shy & Wei-Wen Lin . Norepinephrine transporter polymorphisms T-182C and G1287A are not associated with alcohol dependence and its clinical subgroups . . 92 . 1–3 . 20–26 . January 2008 . 10.1016/j.drugalcdep.2007.06.003 . 17630229.
  4. Soo-Churl Cho, Jae-Won Kim, Boong-Nyun Kim, Jun-Won Hwang, Mira Park, Soon Ae Kim, Dae-Yeon Cho, Hee-Jeong Yoo, Un-Sun Chung, Jung-Woo Son & Tae-Won Park . No evidence of an association between norepinephrine transporter gene polymorphisms and attention deficit hyperactivity disorder: a family-based and case-control association study in a Korean sample . . 57 . 3 . 131–138 . 2008 . 10.1159/000138916 . 18552510. 7062834 .
  5. Piotr Ksiazek, Kinga Buraczynska . Monika Buraczynska . amp . Norepinephrine transporter gene (NET) polymorphism in patients with type 2 diabetes . . 29 . 6 . 338–43 . 2006 . 10.1159/000097356 . 17124432. 25727749 .
  6. Peter Zill, Rolf Engel, Thomas C. Baghai, Georg Juckel, Thomas Frodl, Florian Muller-Siecheneder, Peter Zwanzger, Cornelius Schule, Christo Minov, Stefanie Behrens, Rainer Rupprecht, Ulrich Hegerl, Hans Jurgen Moller & Brigitta Bondy . Identification of a naturally occurring polymorphism in the promoter region of the norepinephrine transporter and analysis in major depression . . 26 . 4 . 489–93 . April 2002 . 10.1016/S0893-133X(01)00386-4 . 11927173. free .
  7. Kazuyuki Inoue, Kunihiko Itoh, Keizo Yoshida, Hisashi Higuchi, Mitsuhiro Kamata, Hitoshi Takahashi, Tetsuo Shimizu & Toshio Suzuki . No association of the G1287A polymorphism in the norepinephrine transporter gene and susceptibility to major depressive disorder in a Japanese population . . 30 . 10 . 1996–1998 . October 2007 . 17917281 . 10.1248/bpb.30.1996. free .
  8. P. G. Sand, T. Mori, C. Godau, G. Stober, P. Flachenecker, P. Franke, M. M. Nothen, J. Fritze, W. Maier, K.-P. Lesch, P. Riederer, H. Beckmann & J. Deckert . Norepinephrine transporter gene (NET) variants in patients with panic disorder . . 333 . 1 . 41–44 . November 2002 . 12401556 . 10.1016/S0304-3940(02)00984-9. 19657809 .
  9. Christopher A. Rippel, Andrew J. Kobets, Dustin Y. Yoon, Phillip N. Williams, Yin Yao Shugart, Dana D. Bridges, David J. Vandenbergh & Harvey S. Singer . Norepinephrine transporter polymorphisms in Tourette syndrome with and without attention deficit hyperactivity disorder: no evidence for significant association . . 16 . 5 . 179–80 . October 2006 . 10.1097/01.ypg.0000218622.96127.71 . 16969268.
  10. J. Samochowiec, F. Rybakowski, P. Czerski, M. Zakrzewska, G. Stepien, J. Pelka-Wysiecka, J. Horodnicki, J. K. Rybakowski & J. Hauser . Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationship to temperamental dimensions measured by the Temperament and Character Inventory in healthy volunteers . . 43 . 4 . 248–53 . 2001 . 11340364 . 10.1159/000054898. 24521817 .

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