Rostafuroxin Explained

Rostafuroxin is a digitoxigenin analog that has been shown to lower blood pressure in an animal model of hypertension.[1] It modulates the effects of the enzyme Na+/K+-ATPase,[1] which maintains sodium and potassium ion gradients across plasma membranes. Rostafuroxin is being studied in clinical trials for the treatment of essential hypertension.[2] [3]

Notes and References

  1. 10.1152/ajpregu.00518.2005. 16467500. Rostafuroxin: An ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 290. 3. R529–R535. 2006. Ferrari. Patrizia. Ferrandi. Mara. Valentini. Giovanni. Bianchi. Giuseppe.
  2. 10.1016/j.BBAdis.2010.01.009. 20083196. Rostafuroxin: An ouabain-inhibitor counteracting specific forms of hypertension. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1802. 12. 1254–1258. 2010. Ferrari. Patrizia. free.
  3. Web site: Efficacy of Rostafuroxin in the Treatment of Essential Hypertension . clinicaltrials.gov.

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